Zhang Qi, Wu Yinxin, Chen Jinlan, Tan Fangshun, Mou Jie, Du Zhuoying, Cai Yuxuan, Wang Bei, Yuan Chengfu
College of Medical Science, China Three Gorges University, Yichang 443002, China.
Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
Curr Pharm Des. 2022;28(7):581-585. doi: 10.2174/1381612827666210830110732.
Muscle blind-like-proteins (MBNL) are a class of tissue-specific RNA metabolism regulators that control pre-messenger RNA-splicing. Inactivation of MBNL can lead to myotonic dystrophy in adults. MBNL is mainly expressed in skeletal muscle, neuron tissue, thymus, liver, and kidney and plays an important role in the ultimate differentiation of muscle cells and neurons. MBNL1 is a member of the MBNL protein family. The inactivation of MBNL1 protein is particularly important in the development of myotonic dystrophy and can lead to cataract formation, abnormal muscle relaxation, cardiac and neurological dysfunction, etc. The induction of MBNL1 in tumors is known to significantly inhibit tumor progression and thus significantly prolong survival. MBNL1 antisense protein MBNL1-AS1 also plays an important role in tumor migration and development.
This review reveals the role of MBNL1 and MBNL1-AS1 in the complex pathogenesis of many tumors, which provide a new target for the treatment of tumors.
Correlated research are systematically retrieved via PubMed. In this review, the role of MBNL1 and MBNL1- AS1 were analyzed.
MBNL1 is down-regulated in breast cancer, leukemia, stomach cancer, esophageal cancer, glioma, and Huntington's disease. The function of inhibiting tumor cell metastasis decreased. It is up-regulated in cervical cancer and colorectal cancer, which can promote the development of tumor cells. Antisense protein MBNL1- AS1 can inhibit tumor cell proliferation and metastasis in colorectal cancer, non-small cell lung cancer, and gastric cancer.
MBNL1 is an important regulator of tumor metastasis and growth, which exhibits a promising therapeutic target and can be further explored.
肌肉盲样蛋白（MBNL）是一类组织特异性RNA代谢调节因子，可控制信使核糖核酸前体（pre-mRNA）剪接。MBNL失活可导致成人患强直性肌营养不良。MBNL主要在骨骼肌、神经组织、胸腺、肝脏和肾脏中表达，在肌肉细胞和神经元的最终分化中起重要作用。MBNL1是MBNL蛋白家族的成员。MBNL1蛋白的失活在强直性肌营养不良的发展中尤为重要，可导致白内障形成、肌肉松弛异常、心脏和神经功能障碍等。已知肿瘤中MBNL1的诱导可显著抑制肿瘤进展，从而显著延长生存期。MBNL1反义蛋白MBNL1-AS1在肿瘤迁移和发展中也起重要作用。
本综述揭示MBNL1和MBNL1-AS1在多种肿瘤复杂发病机制中的作用，为肿瘤治疗提供新靶点。
通过PubMed系统检索相关研究。在本综述中，分析了MBNL1和MBNL1-AS1的作用。
MBNL1在乳腺癌、白血病、胃癌、食管癌、胶质瘤和亨廷顿病中表达下调，抑制肿瘤细胞转移的功能下降。它在宫颈癌和结直肠癌中上调，可促进肿瘤细胞的发展。反义蛋白MBNL1-AS1可抑制结直肠癌、非小细胞肺癌和胃癌中的肿瘤细胞增殖和转移。
MBNL1是肿瘤转移和生长的重要调节因子，是一个有前景的治疗靶点，值得进一步探索。
