Lee Seok-Yun, Lomax Nicoletta, Berkmann Sven, Vollmer Kathrin, Riesterer Oliver, Bodis Stephan, Rogers Susanne
Radio-Onkologie-Zentrum KSA-KSB, Kantonsspital Aarau, Tellstrasse 25, 5001, Aarau, Switzerland.
Klinik für Neurochirurgie, Kantonsspital Aarau, Tellstrasse 25, 5001, Aarau, Switzerland.
Strahlenther Onkol. 2021 Dec;197(12):1143-1147. doi: 10.1007/s00066-021-01814-0. Epub 2021 Aug 30.
A 70-year old male with stage I large cell neuroendocrine carcinoma (LCNEC) of the lung underwent resection of a metachronous 5 cm brain metastasis and received postoperative hypofractionated stereotactic radiotherapy (hfSRT). Five sequential nodular leptomeningeal metastases up to 5.3 cm in diameter were diagnosed on MRI within 10 months and were treated with SRT. Currently the patient has no evidence of intracranial disease 24 months after last irradiation without chemotherapy or whole brain radiotherapy. This is the first report of sustained complete remission of multiple large leptomeningeal metastases achieved with hfSRT, highlighting this brain-sparing approach in selected patients with LCNEC lung cancer.
一名70岁男性，患有I期肺大细胞神经内分泌癌（LCNEC），接受了异时性5厘米脑转移瘤切除术，并接受了术后大分割立体定向放射治疗（hfSRT）。在10个月内，MRI诊断出5个连续的结节性软脑膜转移瘤，直径达5.3厘米，并接受了立体定向放射治疗（SRT）。目前，在最后一次放疗后24个月，患者没有颅内疾病的迹象，未接受化疗或全脑放疗。这是第一份关于hfSRT实现多个大的软脑膜转移瘤持续完全缓解的报告，突出了这种在选定的LCNEC肺癌患者中保留脑功能的方法。
