新型冠状病毒肺炎患者 Th1/Th2 反应及疾病严重程度的相关因素：一项简短报告。
Elements of Th1/Th2 response and disease severity in COVID-19 patients: A short report.
机构信息
Department of Internal Medicine, University of Patras, Rio, Greece.
Department of Infectious Diseases, University of Patras, Rio, Greece.
出版信息
J Med Virol. 2022 Jan;94(1):404-406. doi: 10.1002/jmv.27313. Epub 2021 Sep 4.
Abstract
The presence of a complex immune dysregulation syndrome has been established in COVID-19 patients. We aimed to assess Th1/Th2 response in COVID-19 patients and its association with disease severity by performing a prospective cohort study in a tertiary hospital COVID-19 referral center. We report no difference between Th1/Th2 responses between patients with severe and mild disease, except for levels of interleukin-6 (IL-6) and IL-10. Future larger studies should examine lung-specific versus systemic inflammatory responses, as well as, diverse immunotypes driving poor clinical outcomes.
摘要
已经在 COVID-19 患者中确定存在复杂的免疫失调综合征。我们旨在通过在一家三级医院 COVID-19 转诊中心进行前瞻性队列研究，评估 COVID-19 患者的 Th1/Th2 反应及其与疾病严重程度的关系。我们报告重症和轻症患者之间的 Th1/Th2 反应没有差异，除了白细胞介素 6（IL-6）和白细胞介素 10（IL-10）水平。未来更大的研究应该检查肺部特异性与全身炎症反应，以及导致临床预后不良的不同免疫类型。
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