Casale Roberto
Opusmedica Persons, Care & Research - PC&R, Piacenza, Italy.
Expert Rev Neurother. 2021 Oct;21(10):1147-1158. doi: 10.1080/14737175.2021.1974842. Epub 2021 Oct 11.
The use of topical agents has been suggested for post-surgical neuropathic pain. A high-concentration capsaicin 179-mg cutaneous patch (Qutenza™) is licensed in adults for chronic neuropathic pain in the EU, and neuropathic pain with post-herpetic neuralgia and neuropathic pain with diabetic peripheral neuropathy in the USA. This article aims to describe the use of a topical capsaicin 179-mg cutaneous patch in the treatment of PSNP.
This narrative review presents the relevant clinical aspects of the use of a topical capsaicin 179-mg cutaneous patch for the treatment of post-surgical neuropathic pain (PSNP). Randomized control trials, observational studies, case series, and reports investigating the clinical use of the capsaicin patch were searched through MEDLINE, EMBASE, AMED, Cochrane Library, CINAHL, Web of Science, and ROAD databases. Trials from citation lists of reviewed articles and hand-searching were added. The search concluded in September 2020. 10/20 articles were considered.
Some clinical studies demonstrated the efficacy of the capsaicin 179-mg patch in PSNP as monotherapy and concomitant treatment with oral treatments. This topical treatment of PSNP is better tolerated and accepted compared with systemic treatments. To maximize the effectiveness of the treatment, correct administration recommendations should be followed.
有人建议使用局部用药治疗术后神经性疼痛。高浓度辣椒素179毫克皮肤贴片（Qutenza™）在欧盟被批准用于成人慢性神经性疼痛，在美国被批准用于治疗带状疱疹后神经痛引起的神经性疼痛以及糖尿病性周围神经病变引起的神经性疼痛。本文旨在描述179毫克辣椒素皮肤贴片在治疗术后神经性疼痛中的应用。
本叙述性综述介绍了使用179毫克辣椒素皮肤贴片治疗术后神经性疼痛（PSNP）的相关临床情况。通过MEDLINE、EMBASE、AMED、Cochrane图书馆、CINAHL、科学网和ROAD数据库检索了调查辣椒素贴片临床应用的随机对照试验、观察性研究、病例系列和报告。还补充了综述文章引用列表中的试验和手工检索的结果。检索于2020年9月结束。共纳入10/20篇文章。
一些临床研究表明，179毫克辣椒素贴片作为单一疗法以及与口服治疗联合使用时，对术后神经性疼痛有效。与全身治疗相比，这种局部治疗术后神经性疼痛的耐受性和接受度更好。为了使治疗效果最大化，应遵循正确的给药建议。
