Schraplau Anne, Block Andrea, Häusler Andreas, Wippert Pia-Maria, Rapp Michael A, Völler Heinz, Bonaventura Klaus, Mayer Frank
University Outpatient Clinic, Sports Medicine and Sports Orthopedics, University of Potsdam, Am Neuen Palais 10, 14469, Potsdam, Germany.
Faculty of Health Sciences Brandenburg, University of Potsdam, Potsdam, Germany.
Pilot Feasibility Stud. 2021 Aug 30;7(1):166. doi: 10.1186/s40814-021-00898-w.
The metabolic syndrome (MetS) is a risk cluster for a number of secondary diseases. The implementation of prevention programs requires early detection of individuals at risk. However, access to health care providers is limited in structurally weak regions. Brandenburg, a rural federal state in Germany, has an especially high MetS prevalence and disease burden. This study aims to validate and test the feasibility of a setup for mobile diagnostics of MetS and its secondary diseases, to evaluate the MetS prevalence and its association with moderating factors in Brandenburg and to identify new ways of early prevention, while establishing a "Mobile Brandenburg Cohort" to reveal new causes and risk factors for MetS.
In a pilot study, setups for mobile diagnostics of MetS and secondary diseases will be developed and validated. A van will be equipped as an examination room using point-of-care blood analyzers and by mobilizing standard methods. In study part A, these mobile diagnostic units will be placed at different locations in Brandenburg to locally recruit 5000 participants aged 40-70 years. They will be examined for MetS and advice on nutrition and physical activity will be provided. Questionnaires will be used to evaluate sociodemographics, stress perception, and physical activity. In study part B, participants with MetS, but without known secondary diseases, will receive a detailed mobile medical examination, including MetS diagnostics, medical history, clinical examinations, and instrumental diagnostics for internal, cardiovascular, musculoskeletal, and cognitive disorders. Participants will receive advice on nutrition and an exercise program will be demonstrated on site. People unable to participate in these mobile examinations will be interviewed by telephone. If necessary, participants will be referred to general practitioners for further diagnosis.
The mobile diagnostics approach enables early detection of individuals at risk, and their targeted referral to local health care providers. Evaluation of the MetS prevalence, its relation to risk-increasing factors, and the "Mobile Brandenburg Cohort" create a unique database for further longitudinal studies on the implementation of home-based prevention programs to reduce mortality, especially in rural regions.
German Clinical Trials Register, DRKS00022764 ; registered 07 October 2020-retrospectively registered.
代谢综合征（MetS）是多种继发性疾病的风险集群。预防项目的实施需要早期发现有风险的个体。然而，在结构薄弱地区，获得医疗服务提供者的机会有限。德国的农村联邦州勃兰登堡州的MetS患病率和疾病负担尤其高。本研究旨在验证和测试MetS及其继发性疾病的移动诊断设置的可行性，评估勃兰登堡州的MetS患病率及其与调节因素的关联，并确定早期预防的新方法，同时建立一个“移动勃兰登堡队列”以揭示MetS的新病因和风险因素。
在一项试点研究中，将开发并验证MetS和继发性疾病的移动诊断设置。一辆厢式货车将配备即时检验血液分析仪并采用标准方法，作为检查室。在研究A部分，这些移动诊断单元将放置在勃兰登堡州的不同地点，以在当地招募5000名年龄在40至70岁之间的参与者。他们将接受MetS检查，并获得有关营养和体育活动的建议。问卷将用于评估社会人口统计学、压力感知和体育活动。在研究B部分，患有MetS但无已知继发性疾病的参与者将接受详细的移动医学检查，包括MetS诊断、病史、临床检查以及针对内科、心血管、肌肉骨骼和认知障碍的仪器诊断。参与者将获得营养建议，并将在现场演示一个锻炼计划。无法参加这些移动检查的人将接受电话访谈。如有必要，参与者将被转介给全科医生进行进一步诊断。
移动诊断方法能够早期发现有风险的个体，并将他们有针对性地转介给当地医疗服务提供者。对MetS患病率、其与风险增加因素的关系以及“移动勃兰登堡队列”的评估为进一步开展关于实施家庭预防项目以降低死亡率的纵向研究创建了一个独特的数据库，特别是在农村地区。
德国临床试验注册中心，DRKS00022764；于2020年10月7日注册——追溯注册。
