Jones C D, Laval-Jeantet A M, Laval-Jeantet M H, Genant H K
Department of Radiology, University of Paris.
Bone. 1987;8(4):201-6. doi: 10.1016/8756-3282(87)90165-7.
Quantitative computed tomography (QCT) measurements of bone mineral density, volume, and content were made of the spongious and compact portions of a vertebral body and of the total vertebral body in 19 osteoporotic patients (13 women and 6 men) and 20 normal (control) age- and sex-matched patients. Specifically, CT scans of 10mm thick transverse sections of L2 or L3 of each osteoporotic and control patient were subjected to QCT bone measurement with the use of K2HPO4 calibration for converting CT values into units (mg/ml) equivalent to bone mineral density. In every instance, a significant difference was found in the spongious vertebral bone mineral density (and content) between the osteoporotic and the paired normal groups. Even when the total vertebral bone mineral content was normal, the spongious vertebral bone mineral density was significantly less in the osteoporotic patients. Only in the osteoporotic men was a difference in compact bone density (and content) found; the osteoporotic men had a significantly lower compact bone mineral than did the normal male patients. This study shows that QCT can be applied to measurement of bone mineral density (and content) of both the anterior spongious and the more dense compact vertebral bone from a single section of a lumbar vertebra and that it is the anterior, spongious, vertebral bone rather than the compact vertebral bone that exhibits the more severe decrease in bone mineral density (and content) due to osteoporosis.
