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超声心动图评估心脏淀粉样变性。

Echocardiographic assessment of cardiac amyloidosis.

机构信息

Houston Methodist DeBakey Heart & Vascular Center, 6550 Fannin St, Suite 1801, Houston, TX77030, USA.

出版信息

Heart Fail Rev. 2022 Sep;27(5):1505-1513. doi: 10.1007/s10741-021-10165-y. Epub 2021 Aug 30.

DOI:10.1007/s10741-021-10165-y
PMID:34462900
Abstract

Cardiac amyloidosis, a form of infiltrative cardiomyopathy, is associated with poor prognosis in untreated patients. Early diagnosis is important for timely initiation of effective therapies. Despite advances in diagnostic modalities, it remains a challenging diagnosis, requiring high index of clinical suspicion. Echocardiography represents the first-line cardiac imaging modality for evaluation of heart failure and suspected cardiac amyloidosis. In this review, we discuss echocardiographic findings in cardiac amyloidosis.

摘要

心脏淀粉样变是一种浸润性心肌病，与未经治疗的患者预后不良有关。早期诊断对于及时开始有效的治疗非常重要。尽管诊断方法有所进步，但它仍然是一个具有挑战性的诊断，需要高度的临床怀疑。超声心动图是评估心力衰竭和疑似心脏淀粉样变的一线心脏成像方式。在这篇综述中，我们讨论了心脏淀粉样变的超声心动图表现。

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Echocardiographic assessment of cardiac amyloidosis.超声心动图评估心脏淀粉样变性。
Heart Fail Rev. 2022 Sep;27(5):1505-1513. doi: 10.1007/s10741-021-10165-y. Epub 2021 Aug 30.
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引用本文的文献

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Ann Nucl Med. 2025 Aug 25. doi: 10.1007/s12149-025-02092-x.
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Transthyretin Amyloid Cardiomyopathy: Current Diagnostic Approach and Risk Stratification with Multimodality Imaging.转甲状腺素蛋白淀粉样心肌病：多模态成像的当前诊断方法和风险分层
J Clin Med. 2025 Mar 16;14(6):2014. doi: 10.3390/jcm14062014.
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Case Report: A missed diagnosis of cardiac amyloidosis using echocardiography due to immunoglobulin light chain amyloidosis with normal wall thickness in the early stage.

本文引用的文献

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Prevalence and Outcomes of Concomitant Aortic Stenosis and Cardiac Amyloidosis.并存的主动脉瓣狭窄和心脏淀粉样变性的患病率和结局。
J Am Coll Cardiol. 2021 Jan 19;77(2):128-139. doi: 10.1016/j.jacc.2020.11.006. Epub 2020 Nov 9.
2
Prognostic implications of pericardial and pleural effusion in patients with cardiac amyloidosis.心包和胸腔积液对心脏淀粉样变性患者的预后意义。
Clin Res Cardiol. 2021 Apr;110(4):532-543. doi: 10.1007/s00392-020-01698-7. Epub 2020 Sep 10.
3
Cardiac Amyloidosis: Evolving Diagnosis and Management: A Scientific Statement From the American Heart Association.
病例报告：一例早期免疫球蛋白轻链型淀粉样变导致心脏壁厚度正常，经超声心动图检查漏诊心脏淀粉样变。
Front Cardiovasc Med. 2024 Dec 20;11:1331157. doi: 10.3389/fcvm.2024.1331157. eCollection 2024.
4
A case report of transthyretin amyloidosis following cardiac transplantation: thick ventricles that look alike.心脏移植后转甲状腺素蛋白淀粉样变性病例报告：相似的增厚心室。
Eur Heart J Case Rep. 2024 May 8;8(8):ytae242. doi: 10.1093/ehjcr/ytae242. eCollection 2024 Aug.
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Cardiac cell senescence: molecular mechanisms, key proteins and therapeutic targets.心脏细胞衰老：分子机制、关键蛋白及治疗靶点。
Cell Death Discov. 2024 Feb 14;10(1):78. doi: 10.1038/s41420-023-01792-5.
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It Takes a Village: Multimodality Imaging of Cardiac Amyloidosis.众人拾柴火焰高：心脏淀粉样变性的多模态成像。
Methodist Debakey Cardiovasc J. 2022 Mar 14;18(2):47-58. doi: 10.14797/mdcvj.1072. eCollection 2022.
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Multimodal Imaging and Biomarkers in Cardiac Amyloidosis.心脏淀粉样变性中的多模态成像与生物标志物
Diagnostics (Basel). 2022 Mar 3;12(3):627. doi: 10.3390/diagnostics12030627.
心脏淀粉样变性：不断发展的诊断和治疗——美国心脏协会的科学声明。
Circulation. 2020 Jul 7;142(1):e7-e22. doi: 10.1161/CIR.0000000000000792. Epub 2020 Jun 1.
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