Laboratoire de Chimie, Ens de Lyon, CNRS UMR 5182, Lyon, France.
Institut des Sciences Moléculaires, CNRS UMR 5255, Bordeaux University, Talence, France.
Chirality. 2021 Oct;33(10):562-596. doi: 10.1002/chir.23347. Epub 2021 Aug 31.
This review addresses the synthesis of enantiopure cryptophane and the study of their chiroptical properties. Cryptophane derivatives represent an important class of macrocyclic compounds that can bind a large range of species in solution under different conditions. The overwhelming majority of these host molecules is chiral, and their chiroptical properties have been thoroughly investigated. The first part of this review is dedicated to the optical resolution and the synthesis of enantiopure cryptophane derivatives. In a second part, the study of the chiroptical properties of these molecular hosts by different techniques such as electronic and vibrational circular dichroism and Raman optical activity is detailed. These techniques allow the determination of the absolute configuration of cryptophane derivatives and provide useful information about their conformation in different conditions.
本文综述了对映纯 cryptophane 的合成及手性光学性质的研究。cryptophane 衍生物是一类重要的大环化合物，在不同条件下可以在溶液中结合多种物质。这些主体分子绝大多数是手性的，其手性光学性质已经得到了深入研究。本文综述的第一部分致力于对映纯 cryptophane 衍生物的光学拆分和合成。第二部分详细介绍了通过电子和振动圆二色性以及拉曼光学活性等不同技术研究这些分子主体的手性光学性质。这些技术可以确定 cryptophane 衍生物的绝对构型，并提供有关其在不同条件下构象的有用信息。
