脐带间充质干细胞通过分泌 CXCL1 促进髓源性抑制细胞富集，以防止造血干细胞移植后移植物抗宿主病。
Umbilical cord-derived mesenchymal stem cells promote myeloid-derived suppressor cell enrichment by secreting CXCL1 to prevent graft-versus-host disease after hematopoietic stem cell transplantation.
机构信息
Medical Center of Hematology, Xinqiao Hospital, State Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, China.
Department of Cell Biology, College of Basic Medicine, Third Military Medical University (Army Medical University), Chongqing, China.
出版信息
Cytotherapy. 2021 Nov;23(11):996-1006. doi: 10.1016/j.jcyt.2021.07.009. Epub 2021 Aug 29.
BACKGROUND AIMS
Human mesenchymal stem cells (MSCs) from various tissues have emerged as attractive candidates for the prevention and treatment of graft-versus-host disease (GVHD). However, the molecular machinery that defines and channels the behavior of these cells remains poorly understood.
METHODS
In this study, the authors compared the efficacy of four tissue-derived MSC types in controlling GVHD in a murine model and investigated their immunomodulatory effects.
RESULTS
Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) effectively decreased the incidence and severity of GVHD, which was mediated by the enrichment of myeloid-derived suppressor cells in GVHD target tissues. RNA sequencing results showed that hUCMSCs highly expressed CXCL1.
CONCLUSIONS
These results suggest a novel prophylactic application of hUCMSCs for controlling GVHD after allogeneic hematopoietic stem cell transplantation.
背景目的
各种组织来源的人骨髓间充质干细胞（MSC）已成为防治移植物抗宿主病（GVHD）的有吸引力的候选者。 然而，定义和引导这些细胞行为的分子机制仍知之甚少。
方法
在这项研究中，作者比较了四种组织来源的 MSC 类型在控制小鼠模型中 GVHD 的功效，并研究了它们的免疫调节作用。
结果
人脐带间充质干细胞（hUCMSC）可有效降低 GVHD 的发生率和严重程度，这是通过在 GVHD 靶组织中髓样来源的抑制细胞的富集介导的。 RNA 测序结果表明 hUCMSC 高度表达 CXCL1。
结论
这些结果表明 hUCMSC 可用于预防异基因造血干细胞移植后 GVHD 的发生。
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