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沃顿胶间充质干细胞：用于减轻辐射损伤的临床应用的未来再生医学。

Wharton's jelly mesenchymal stem cells: Future regenerative medicine for clinical applications in mitigation of radiation injury.

作者信息

Sharma Prashasti, Maurya Dharmendra Kumar

机构信息

Life Sciences, Homi Bhabha National Institute, Mumbai 400094, Maharashtra, India.

Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400085, Maharashtra, India.

出版信息

World J Stem Cells. 2024 Jul 26;16(7):742-759. doi: 10.4252/wjsc.v16.i7.742.

DOI:10.4252/wjsc.v16.i7.742
PMID:39086560
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11287430/
Abstract

Wharton's jelly mesenchymal stem cells (WJ-MSCs) are gaining significant attention in regenerative medicine for their potential to treat degenerative diseases and mitigate radiation injuries. WJ-MSCs are more naïve and have a better safety profile, making them suitable for both autologous and allogeneic transplantations. This review highlights the regenerative potential of WJ-MSCs and their clinical applications in mitigating various types of radiation injuries. In this review, we will also describe why WJ-MSCs will become one of the most probable stem cells for future regenerative medicine along with a balanced view on their strengths and weaknesses. Finally, the most updated literature related to both preclinical and clinical usage of WJ-MSCs for their potential application in the regeneration of tissues and organs will also be compiled.

摘要

沃顿胶间充质干细胞（WJ-MSCs）因其在治疗退行性疾病和减轻辐射损伤方面的潜力，在再生医学领域正受到广泛关注。WJ-MSCs更为原始，安全性更高，适用于自体移植和异体移植。本综述着重介绍了WJ-MSCs的再生潜力及其在减轻各类辐射损伤中的临床应用。在本综述中，我们还将阐述WJ-MSCs成为未来再生医学最具潜力干细胞之一的原因，并对其优缺点进行全面分析。最后，还将汇编与WJ-MSCs在组织和器官再生潜在应用的临床前和临床使用相关的最新文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b1/11287430/ea716d79b812/WJSC-16-742-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b1/11287430/2688a8c7d29f/WJSC-16-742-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b1/11287430/69c821e1a636/WJSC-16-742-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b1/11287430/1294737f1863/WJSC-16-742-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b1/11287430/abec312e60bb/WJSC-16-742-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b1/11287430/0112385c82a6/WJSC-16-742-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b1/11287430/ea716d79b812/WJSC-16-742-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b1/11287430/2688a8c7d29f/WJSC-16-742-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b1/11287430/69c821e1a636/WJSC-16-742-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b1/11287430/1294737f1863/WJSC-16-742-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b1/11287430/abec312e60bb/WJSC-16-742-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b1/11287430/0112385c82a6/WJSC-16-742-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b1/11287430/ea716d79b812/WJSC-16-742-g006.jpg

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本文引用的文献

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Mesenchymal Stromal Cells: Heterogeneity and Therapeutical Applications.间质基质细胞：异质性与治疗应用。
Cells. 2023 Aug 10;12(16):2039. doi: 10.3390/cells12162039.
3
Regenerative medicine applications: An overview of clinical trials.再生医学应用：临床试验概述
比较性突破：脐带间充质干细胞与骨髓间充质干细胞在心力衰竭治疗中的比较
World J Cardiol. 2024 Dec 26;16(12):776-780. doi: 10.4330/wjc.v16.i12.776.
4
Potential plausible role of Wharton's jelly mesenchymal stem cells for diabetic bone regeneration.沃顿胶间充质干细胞在糖尿病性骨再生中的潜在合理作用。
World J Stem Cells. 2024 Aug 26;16(8):824-826. doi: 10.4252/wjsc.v16.i8.824.
Front Bioeng Biotechnol. 2022 Nov 25;10:942750. doi: 10.3389/fbioe.2022.942750. eCollection 2022.
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Soluble factors secreted by human Wharton's jelly mesenchymal stromal/stem cells exhibit therapeutic radioprotection: A mechanistic study with integrating network biology.人脐带华通氏胶间充质基质/干细胞分泌的可溶性因子具有治疗性辐射防护作用：一项整合网络生物学的机制研究
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