Department of Pediatrics, KEM Hospital Research Centre, Pune, India.
Department of Pediatrics, Institute of Child Heath, Kolkata, India.
Indian Pediatr. 2021 Aug 15;58(8):709-717.
To estimate the disease and economic burden of pertussis amongst hospitalised infants in India.
Multicentric hospital-based surveillance study.
Hospitalised infants with clinical suspicion of pertussis based on predefined criteria.
Proportion of infants with laboratory-confirmed pertussis, economic burden of pertussis amongst hospitalised infants.
693 clinically suspected infants were recruited of which 32 (4.62%) infants had laboratory-confirmed pertussis. Progressive cough with post-tussive emesis (50%) and pneumonia (34%) were the common clinical presentations; apnea in young infants was significantly associated with pertussis. Infants with pertussis were more likely to be younger (median age 102.5 days vs.157 days) and born preterm (42.9% vs 24.5%). Almost 30% infants with pertussis had not received vaccine for pertussis with 50% of these infants aged less than 2 months. Pertussis was associated with higher costs of hospitalisation, pharmacy and loss of working days by caregivers as compared to non-pertussis cases.
Younger infants, those born preterm and those inadequately immunised against pertussis are at higher risk of pertussis infection. Timely childhood immunisation and introduction of maternal immunisation for pertussis can help in reducing the disease burden.
估计印度住院婴儿百日咳的疾病和经济负担。
多中心基于医院的监测研究。
根据预设标准有临床疑似百日咳的住院婴儿。
实验室确诊百日咳婴儿的比例，住院婴儿百日咳的经济负担。
共招募了 693 名有临床疑似症状的婴儿，其中 32 名（4.62%）婴儿实验室确诊为百日咳。以痉咳后呕吐（50%）和肺炎（34%）为常见临床表现；婴幼儿呼吸暂停与百日咳显著相关。百日咳婴儿更可能年龄较小（中位数年龄 102.5 天 vs.157 天）且早产（42.9% vs.24.5%）。约 30%的百日咳婴儿未接种百日咳疫苗，其中 50%的婴儿年龄小于 2 个月。与非百日咳病例相比，百日咳婴儿的住院、药房和照顾者的工作日损失费用更高。
年龄较小、早产儿和未充分接种百日咳疫苗的婴儿患百日咳的风险更高。及时进行儿童免疫接种和为百日咳实施母体免疫接种有助于降低疾病负担。
