Viswanathan Rajlakshmi, Bafna Sanjay, Choudhary Manohar Lal, Reddy Monika, Katendra Savita, Maheshwari Shradha, Jadhav Sheetal
Bacteriology Group, ICMR-National Institute of Virology, 130/1, Sus Road, Pashan, Pune 411021, India.
Department of Pediatric Medicine, Jehangir Hospital, 32, Sassoon Road, Pune 411001, India.
Vaccines (Basel). 2022 Jul 27;10(8):1191. doi: 10.3390/vaccines10081191.
Pertussis, commonly known as whooping cough, is one of the most poorly controlled vaccine-preventable diseases in the world. South-East Asia is estimated to contribute the most to childhood disease burden while this remains largely unexplored in India. The clinical diagnosis of pertussis in young children is a challenge as the classical four-stage presentation with paroxysmal cough or whoop may be absent. It is also difficult to differentiate from other respiratory infections which can cause pertussis-like illness. Children below two years with prolonged cough illness attending an urban pediatric center in western India, were evaluated for pertussis and viral infections by molecular methods. and were confirmed in three each of 45 suspected cases, and RSV-A and hMPV were the most common viruses that were detected. These organisms can mimic mild cases of pertussis and need to be considered in differential diagnosis of prolonged cough illness in young children. The accurate etiology of prolonged cough illness needs to be detected and documented to ensure appropriate management and accurate estimates of disease burden.
百日咳，俗称“哮吼性咳嗽”，是世界上控制最不力的疫苗可预防疾病之一。据估计，东南亚对儿童疾病负担的贡献最大，而在印度，这方面很大程度上仍未得到充分研究。幼儿百日咳的临床诊断具有挑战性，因为可能不存在伴有阵发性咳嗽或哮吼的典型四阶段表现。也很难与其他可导致百日咳样疾病的呼吸道感染相区分。对印度西部一家城市儿科中心就诊的患有持续性咳嗽疾病的两岁以下儿童，采用分子方法对百日咳和病毒感染进行了评估。在45例疑似病例中，分别有3例确诊为百日咳杆菌和副百日咳杆菌，检测到的最常见病毒是呼吸道合胞病毒A和人偏肺病毒。这些病原体可模仿轻度百日咳病例，在幼儿持续性咳嗽疾病的鉴别诊断中需要予以考虑。需要检测并记录持续性咳嗽疾病的准确病因，以确保进行适当管理并准确估计疾病负担。
