Al-Wassia Rolina K, Iskanderani Omar
Department of Radiology, Radiation Oncology Unit, King Abdulaziz University Hospital, P.O. Box 80200, Jeddah 21589, Saudi Arabia.
Saudi J Biol Sci. 2021 Sep;28(9):5042-5047. doi: 10.1016/j.sjbs.2021.05.017. Epub 2021 May 13.
Stereotactic radiosurgery (SRS), a non-invasive surgical procedure had been utilized for treatment of patients with brain metastases. This study aims to determine the survival, local control of brain metastases and treatment outcome to SRS-treated patients based on radiological imaging.
The MRI scans of SRS-treated patients with brain metastases (n = 24) from the Radiology Department of King Abdulaziz University from January 2016 to September 2019 were examined. The data was analyzed using descriptive statistics and Chi-square test.
Out of 24 patients, most had brain metastases (95.8%, n = 23) with mean interval development (after primary site) of 21.88 ± 25.2 months. Radiological imaging revealed tumor characteristics of smallest (n = 11) and biggest lesions (n = 24) of patients to be 0.98 ± 0.7 and 2.23 ± 0.9, respectively and number of lesion to be 4-5 lesions (n = 3), 3 lesions (n = 6), 2 lesions (n = 4) and 1 lesion (n = 11). After SRS treatment, findings showed 17.6% (n = 3) no recurrence among the patients. Those with recurrences have decrease in lesion enhancement (11.8%, n = 2), decrease in size (29.4%, n = 5) and decrease in both enhancement and size (29.4%). Overall survival obtained was 16.7% (n = 2) at 313.83 ± 376.0 days (n = 23) survival period. Chi-square test showed that radiological findings were significantly associated with tumor recurrence (), having SRS-treated patients with recurrences (n = 12) to experience significant decrease () in tumor enhancement, size, and both enhancement and size.
A significant decrease in tumor size and enhancement was observed in SRS-treated patients, suggesting SRS treatment to have associated benefit with prolonged survival duration.
立体定向放射外科手术（SRS）是一种非侵入性手术，已被用于治疗脑转移瘤患者。本研究旨在根据影像学检查确定接受SRS治疗患者的生存率、脑转移瘤的局部控制情况及治疗结果。
对2016年1月至2019年9月在阿卜杜勒阿齐兹国王大学放射科接受SRS治疗的24例脑转移瘤患者的MRI扫描图像进行检查。采用描述性统计和卡方检验对数据进行分析。
24例患者中，大多数患有脑转移瘤（95.8%，n = 23），平均间隔期（原发部位之后）为21.88±25.2个月。影像学检查显示，患者最小病灶（n = 11）和最大病灶（n = 24）的肿瘤特征分别为0.98±0.7和2.23±0.9，病灶数量为4 - 5个（n = 3）、3个（n = 6）、2个（n = 4）和1个（n = 11）。SRS治疗后，结果显示17.6%（n = 3）的患者无复发。复发患者中，病灶强化程度降低（11.8%，n = 2）、大小减小（29.4%，n = 5）以及强化程度和大小均减小（29.4%）。在313.83±376.0天（n = 23）的生存期内，总体生存率为16.7%（n = 2）。卡方检验表明，影像学检查结果与肿瘤复发显著相关（），接受SRS治疗的复发患者（n = 12）的肿瘤强化程度、大小以及强化程度和大小均显著降低（）。
在接受SRS治疗的患者中观察到肿瘤大小和强化程度显著降低，提示SRS治疗对延长生存期有相关益处。
