硫唑嘌呤诱发严重骨髓抑制伴大量脱发及口腔溃疡，见于一例自身免疫性肝炎微小变异型患者：病例报告
Azathioprine-induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with minor variant: A case report.
作者信息
Takeuchi Yu, Noritake Hidenao, Matsumoto Moe, Umemura Masahiro, Yamashita Maho, Kitsugi Kensuke, Takatori Shingo, Ohta Kazuyoshi, Ito Jun, Shimoyama Shin, Kaysuya Akira, Maruyama Chiaki, Fukuchi Kensuke, Dohtan Satoshi, Sakata Hiroe, Kawata Kazuhito
机构信息
Division of Hepatology Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan.
Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan.
出版信息
Clin Case Rep. 2021 Aug 25;9(8):e04696. doi: 10.1002/ccr3.4696. eCollection 2021 Aug.
This report highlights azathioprine-induced severe myelosuppression in the patient with NUDT15 minor variant. This case report is particularly instructive because several typical symptoms are the clues to this critical adverse drug reaction.
本报告强调了携带NUDT15次要变异体的患者中硫唑嘌呤诱导的严重骨髓抑制。该病例报告特别具有指导意义，因为几个典型症状是这种严重药物不良反应的线索。
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