Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
Medical Research Council Cancer Unit, University of Cambridge, Box 197, Biomedical Campus, Cambridge CB2 0XZ, UK.
Mol Cell. 2021 Sep 16;81(18):3749-3759. doi: 10.1016/j.molcel.2021.08.005. Epub 2021 Aug 31.
The expression of the urea cycle (UC) proteins is dysregulated in multiple cancers, providing metabolic benefits to tumor survival, proliferation, and growth. Here, we review the main changes described in the expression of UC enzymes and metabolites in different cancers at various stages and suggest that these changes are dynamic and should hence be viewed in a context-specific manner. Understanding the evolvability in the activity of the UC pathway in cancer has implications for cancer-immune cell interactions and for cancer diagnosis and therapy.
尿素循环（UC）蛋白的表达在多种癌症中失调，为肿瘤的存活、增殖和生长提供了代谢益处。在这里，我们回顾了不同癌症在不同阶段描述的 UC 酶和代谢物表达的主要变化，并提出这些变化是动态的，因此应该以特定于上下文的方式来看待。了解 UC 通路在癌症中的活性的可变性对癌症-免疫细胞相互作用以及癌症的诊断和治疗具有重要意义。
