无金属选择性氧化 4-甲基喹啉为喹啉-4-醛
Metal-Free Chemoselective Oxidation of 4-Methylquinolines into Quinoline-4-Carbaldehydes.
机构信息
Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai, 200438, P. R China.
Department of Hematology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, P. R China.
出版信息
Chem Asian J. 2021 Oct 18;16(20):3114-3117. doi: 10.1002/asia.202100704. Epub 2021 Sep 2.
PMID:34472705
Abstract
A convenient protocol for the synthesis of quinoline-4-carbaldehydes via chemoselective oxidation of 4-methylquinolines using hypervalent iodine(III) reagents as oxidant is described. This method highlights metal-free and mild reaction conditions, nice yield, good functional group tolerance, and high chemoselectivity.
摘要
描述了一种通过使用高价碘(III)试剂作为氧化剂对 4-甲基喹啉进行选择性氧化来合成喹啉-4-甲醛的方便方法。该方法的特点是无金属、反应条件温和、产率高、官能团耐受性好、化学选择性高。
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