Transition-Metal-Free Sulfoximidation of Sulfonylhydrazones for the Synthesis of -Sulfanylidenehydrazonamides.
作者信息
Huang Tianming, Suleman Muhammad, Xu Zhengyu, Wei Li, Yang Yi, Zhang Ming, Chen Zhiyuan
机构信息
College of Chemistry & Chemical Engineering, Jiangxi Normal University, 330022 Nanchang, China.
Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, 310015 Hangzhou, Zhejiang, China.
出版信息
Org Lett. 2024 Aug 9;26(31):6597-6601. doi: 10.1021/acs.orglett.4c02170. Epub 2024 Jul 26.
Herein, we report a transition-metal-free C-H bond sulfoximidation protocol of sulfonyl hydrazones with hypervalent iodine(III) reagents. A library of novel -sulfaneylidenehydrazonamides was constructed via chemoselective C-N bond formation reactions at aldehyde C-H bonds of sulfonyl hydrazones in the presence of a base. The reaction demonstrated broad substrate group diversity under exceedingly mild reaction conditions, and excellent yields were achieved at room temperature.
Zotero 插件