Marjanowski Simon David, Maldonado Alejandra, Schaller Benoît, Burkhard John-Patrik Matthias
Universitätsklinik für Schädel-, Kiefer- und Gesichtschirurgie, Inselspital, Universitätsspital Bern.
Swiss Dent J. 2021 Sep 6;131(9):713-718. doi: 10.61872/sdj-2021-09-03.
Osteoradionecrosis (ORN) is a serious complication after radiotherapy for head and neck cancer and is a challenging condition for both the therapist and the patient because of its difficult treatment. Different non-invasive approaches have been published for the treatment of low-grade ORN cases without establishing a standard regimen for treatment. Based on the approach of ORN pathogenesis, the so-called radiatio-induced fibroathrophic process (RIF), a new treatment concept with pentoxifylline and tocopherol (PENTO) has been published. The results of PENTO therapy seem promising as a conservative treatment approach for mild ORN or as an alternative when surgical intervention is not possible or desired. The present study summarizes the current state of the literature and shows the effectiveness of PENTO therapy based on a case report.
放射性骨坏死（ORN）是头颈部癌放疗后的一种严重并发症，因其治疗困难，对治疗师和患者来说都是一项具有挑战性的病症。针对低度ORN病例的治疗，已发表了不同的非侵入性方法，但尚未确立标准治疗方案。基于ORN发病机制，即所谓的放射诱导纤维萎缩过程（RIF），一种使用己酮可可碱和生育酚（PENTO）的新治疗理念已被发表。PENTO疗法作为轻度ORN的保守治疗方法，或在无法进行或不希望进行手术干预时作为替代方法，其结果似乎很有前景。本研究总结了当前文献的现状，并基于一例病例报告展示了PENTO疗法的有效性。
