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仔猪出生后早期血清蛋白电泳图谱。

Serum protein electrophoretic pattern in piglets during the early postnatal period.

机构信息

Clinic of Ruminants, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 81, Košice, Slovak Republic.

Clinic of Swine, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 01, Košice, Slovak Republic.

出版信息

Sci Rep. 2021 Sep 2;11(1):17539. doi: 10.1038/s41598-021-96957-6.

DOI:10.1038/s41598-021-96957-6
PMID:34475487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8413273/
Abstract

The pattern of serum proteins, the typical features of the electrophoretogram in newborn piglets and during their postnatal development is not completely described. Therefore, the aim of this study was to characterize the changes in serum protein electrophoretic pattern and features of the electrophoretograms during the early postnatal period. Significant changes during the monitored period were found in all evaluated parameters (P < 0.001). The most marked changes were observed mainly in the period before weaning. The concentrations of total proteins, albumin and γ-globulins were before colostrum intake low, γ-globulins represented the smallest proportion of protein fractions. The proportion of α-globulins was after birth a dominant protein fraction. Significant increase of total proteins, α-, β- and γ-globulins and decrease of α-globulins was found 2 days after colostrum intake. The albumin and A/G values increased after birth gradually until weaning. After weaning a significant changes were found in absolute concentrations of total protein and albumin, and in relative values of β-globulin fractions. Presented results showed marked developmental alterations in the serum protein pattern in piglets along with the age. The study also brings new knowledge in the field of description of typical features of electrophoretograms in the observed period of piglet's life.

摘要

血清蛋白模式、新生仔猪及其出生后发育过程中电泳图谱的典型特征尚未完全描述。因此,本研究旨在描述血清蛋白电泳图谱在早期产后阶段的变化特征和电泳图谱的特征。在监测期间,所有评估参数均发生了显著变化(P<0.001)。在所有评估参数中,观察到的变化在监测期间最为显著(P<0.001)。在哺乳期前的观察期内,主要观察到明显的变化。在摄入初乳之前,总蛋白、白蛋白和γ球蛋白的浓度较低,γ球蛋白在蛋白质分数中所占比例最小。α球蛋白的比例是出生后的主要蛋白质。在摄入初乳后 2 天,发现总蛋白、α、β和γ球蛋白显著增加,而α球蛋白减少。白蛋白和 A/G 值在出生后逐渐增加,直到断奶。断奶后,总蛋白和白蛋白的绝对浓度以及β球蛋白相对值发生了显著变化。研究结果表明,仔猪的血清蛋白模式随着年龄的增长而发生显著的发育变化。本研究还为仔猪生命观察期电泳图谱的典型特征描述提供了新的知识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49ce/8413273/a849a9ca3057/41598_2021_96957_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49ce/8413273/c0a1a9e1658e/41598_2021_96957_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49ce/8413273/a849a9ca3057/41598_2021_96957_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49ce/8413273/c0a1a9e1658e/41598_2021_96957_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49ce/8413273/a849a9ca3057/41598_2021_96957_Fig2_HTML.jpg

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