Liu Shubin
Research Computing Center, University of North Carolina, Chapel Hill, North Carolina 27599-3420, United States.
Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599-3290, United States.
J Phys Chem Lett. 2021 Sep 16;12(36):8720-8725. doi: 10.1021/acs.jpclett.1c02433. Epub 2021 Sep 3.
There are different kinds of molecular chirality, such as zero-dimensional point chirality, one-dimensional axial chirality, 2D planar chirality, and 3D chirality. When they coexist in one system, such as in helical structures of proteins and DNA, they form a chirality hierarchy. Earlier, we showed that the chirality propensity of a lower level in a hierarchy is dictated by that of a higher level and henceforth proposed the . In this work, we confirm the validity of this principle in the three-blade propeller molecular system. Our results show that the preference of the 0D chirality of a functional group in the propeller system is determined by the 1D chirality, and homochirality is also a remarkable feature for this system. The establishment and confirmation of the from this work should find important applications in asymmetric synthesis, macromolecular assembly, and many others.
存在不同种类的分子手性，例如零维点手性、一维轴手性、二维平面手性和三维手性。当它们共存于一个体系中时，比如在蛋白质和DNA的螺旋结构中，它们会形成一个手性层级。此前，我们表明层级中较低水平的手性倾向由较高水平的手性倾向决定，并据此提出了……在这项工作中，我们在三叶螺旋桨分子体系中证实了这一原理的有效性。我们的结果表明，螺旋桨体系中官能团的零维手性偏好由一维手性决定，并且同手性也是该体系的一个显著特征。这项工作中……的建立和证实应在不对称合成、大分子组装等诸多领域找到重要应用。
