利用关键转录依赖性：ZMYND8 和 IRF8 在 AML 中的作用。

Exploiting a key transcriptional dependency: ZMYND8 and IRF8 in AML.

机构信息

Departments of Cell Biology, and of Medicine, Blood Cancer Institute, Albert Einstein Cancer Center; and Ruth L. and David S. Gottesman Institute for Stem Cell Research and Regenerative Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.

出版信息

Mol Cell. 2021 Sep 2;81(17):3445-3446. doi: 10.1016/j.molcel.2021.08.013.

DOI:10.1016/j.molcel.2021.08.013

PMID:34478652

Abstract

In this issue of Molecular Cell, Cao et al. (2021) report that AML cells are specifically addicted to an IRF8-MEF2D gene expression network. Furthermore, they identify a chromatin reader, ZMYND8, as the upstream regulator of the IRF8-MEF2D program whose activity is critical for AML cell survival.

摘要

在本期《分子细胞》中，曹等人（2021 年）报告称 AML 细胞特别依赖于一个 IRF8-MEF2D 基因表达网络。此外，他们还确定了一个染色质阅读器 ZMYND8，作为 IRF8-MEF2D 程序的上游调节剂，其活性对于 AML 细胞的存活至关重要。