小型综述：疑似非阿尔茨海默病的病理生理学

Mini-review: The suspected non-Alzheimer's disease pathophysiology.

作者信息

Rizzi Liara, Balthazar Marcio L F

机构信息

Department of Neurology, University of Campinas (UNICAMP), Campinas, SP, Brazil.

出版信息

Neurosci Lett. 2021 Nov 1;764:136208. doi: 10.1016/j.neulet.2021.136208. Epub 2021 Aug 31.

DOI:10.1016/j.neulet.2021.136208

PMID:34478819

Abstract

Suspected non-Alzheimer's disease pathophysiology (SNAP) is a biomarker-based concept that underlying etiology has not been completely understood. Refers to a group of individuals that are negative for amyloid biomarkers and positive for p-Tau and/or neurodegeneration. SNAP causes great research interest because it is not clear if they have a different biological basis from Alzheimer's disease (AD), or are in an early stage of AD itself. The pathological processes behind SNAP need to be clarified. This mini-review aims to summarize the main characteristics of SNAP, besides reporting challenges and promising biomarkers related to the concept.

摘要

疑似非阿尔茨海默病病理生理学（SNAP）是一个基于生物标志物的概念，其潜在病因尚未完全明确。指的是一组淀粉样蛋白生物标志物呈阴性、p- tau和/或神经退行性变呈阳性的个体。SNAP引起了极大的研究兴趣，因为尚不清楚它们是否具有与阿尔茨海默病（AD）不同的生物学基础，或者是否处于AD本身的早期阶段。SNAP背后的病理过程需要阐明。本综述旨在总结SNAP的主要特征，同时报告与该概念相关的挑战和有前景的生物标志物。