Hughes I A, Evans B A
Department of Child Health, University of Wales College of Medicine, Cardiff, UK.
Horm Res. 1987;28(1):25-9. doi: 10.1159/000180921.
Androgen receptor binding was studied in genital skin fibroblasts from 49 patients with androgen insensitivity syndrome (AIS) classified as complete (CAIS) or partial (PAIS) based on the clinical phenotype. The majority (64%) of CAIS and a minority (7%) of PAIS patients were receptor negative. Only 3 receptor-positive AIS cell strains of 30 studied failed to show an increase in specific receptor binding after prolonged androgen exposure in vitro. The gene coding for the androgen receptor in such patients appears intact.
基于临床表型，对49例雄激素不敏感综合征（AIS）患者的生殖器皮肤成纤维细胞进行了雄激素受体结合研究，这些患者分为完全型（CAIS）或部分型（PAIS）。大多数（64%）CAIS患者和少数（7%）PAIS患者受体呈阴性。在研究的30株受体阳性AIS细胞系中，只有3株在体外长时间暴露于雄激素后未显示特异性受体结合增加。此类患者中编码雄激素受体的基因似乎完整无损。
