Inhibition of carbonic anhydrase II by sulfonamide derivatives.

A series of sulfonamide derivatives were synthesized, and the enzyme inhibitory activity of the synthesized compounds on carbonic anhydrase II was evaluated. Through molecular docking studies, it was found that compounds , , , , have a strong binding affinity to carbonic anhydrase II. The IC values of the four compounds , , , and were lower than that of the positive control drug acetazolamide. What's more, the compounds had a high inhibitory activity for A549 lung cancer cell growth, among them, and could inhibit both carbonic anhydrase II and lung cancer cell proliferation.