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利用国家再入院数据库评估 Watchman 装置经皮腔内左心耳封堵术后早期再入院的独立临床预测因素。

Assessment of independent clinical predictors of early readmission after percutaneous endoluminal left atrial appendage closure with the Watchman device using National Readmission Database.

机构信息

Department of Internal Medicine, University of South Alabama University Hospital, Mobile, AL, United States of America.

Department of Cardiovascular Medicine, University of South Alabama University Hospital, Mobile, AL, United States of America.

出版信息

Int J Cardiol. 2021 Nov 15;343:21-26. doi: 10.1016/j.ijcard.2021.08.043. Epub 2021 Sep 2.

Abstract

BACKGROUND

Percutaneous endoluminal left atrial appendage closure (pLAAC) procedure has been used to prevent strokes in patients who are not eligible for long-term prophylactic anticoagulation. Since its approval, multiple studies have looked at its efficacy with comparable outcomes to anticoagulation, the current standard of care.

OBJECTIVES

To assess the readmission rate and determine the factors associated with readmission after the endocardial pLAAC procedure using the Watchman device.

METHODS

Data was obtained from the National Readmission Database (NRD), and we used SPSS software to determine statistically significant clinical predictors affecting readmission after implantation of the Watchman device at 30 days.

RESULTS

The rate of readmission was found to be 9.2%. The true median cost of index hospitalization for the total population in the study was found to be [median (interquartile range = IQR), p] USD 24594 (USD 18883-31,041), whereas the true median cost of admission for those who were getting readmitted after 30 days was [median (IQR)] USD 7699 (USD 4955-14,243). Multivariate analysis of all clinically relevant predictors showed adjusted ratio for [adjusted odds ratio (OR), 95% confidence interval (95% CI), p-value] female genders (1.288, 1.104-1.503, p = 0.001), discharge to home health care (6.155, 1.509-25.096, p = 0.01), chronic kidney disease (CKD) (1.847,1.511-2.258, p < 0.001), chronic lung disease (1.419, 1.194-1.686, p < 0.001), heart failure (1.280, 1.040-1.574, p = 0.02), pericardial disorders (1.485, 1.011-2.179, p = 0.04), fluid and electrolyte disorders (1.456,1.050-2.018, p = 0.02) in those who were getting readmitted at 30-days compared to those who were not readmitted. The median length of stay for the index hospitalization was found to be one day, whereas the median length of stay at the 30-day readmission was reported to be [Median (IQR)] 4 days (2-6 days). Major cardiac reasons for readmission were heart failure, arrhythmias, and pericardial disorders.

CONCLUSION

Our study aims to assess 30-day outcomes in the US population after pLAAC using a Watchman device. Our analysis showed that one in ten patients were getting readmitted. In addition, chronic kidney disease, chronic obstructive pulmonary disease, heart failure, and pericardial disorders were associated with higher readmission rates. These findings will help us assess clinical correlations and predict which patients are more at risk of readmission after a Watchman procedure.

摘要

背景

经皮腔内左心耳封堵术(pLAAC)已被用于预防不符合长期预防性抗凝治疗条件的患者发生中风。该手术自获得批准以来,多项研究已经评估了其疗效,发现与当前的标准治疗方法——抗凝治疗相当。

目的

使用 Watchman 装置评估经皮腔内左心耳封堵术(pLAAC)术后的再入院率,并确定与再入院相关的因素。

方法

从全国再入院数据库(NRD)获取数据,并使用 SPSS 软件在 30 天内确定影响 Watchman 装置植入后再入院的统计学显著的临床预测因素。

结果

再入院率为 9.2%。研究中总人群的指数住院治疗真实中位数费用为[中位数(四分位距=IQR),p]24594 美元(18883-31041 美元),而 30 天后再入院的真实中位数费用为[中位数(IQR)]7699 美元(4955-14243 美元)。对所有临床相关预测因素的多变量分析显示,女性(1.288,1.104-1.503,p=0.001)、出院至家庭保健(6.155,1.509-25.096,p=0.01)、慢性肾脏病(CKD)(1.847,1.511-2.258,p<0.001)、慢性阻塞性肺疾病(1.419,1.194-1.686,p<0.001)、心力衰竭(1.280,1.040-1.574,p=0.02)、心包疾病(1.485,1.011-2.179,p=0.04)、液体和电解质紊乱(1.456,1.050-2.018,p=0.02)等因素与 30 天再入院相关,与未再入院的患者相比,这些因素使再入院的调整比值比(adjusted odds ratio,OR)分别为[调整 OR(95%置信区间,95%CI),p 值]1.288(1.104-1.503,p=0.001)。索引住院的中位住院时间为 1 天,而 30 天再入院的中位住院时间为[中位数(IQR)]4 天(2-6 天)。再入院的主要心脏原因是心力衰竭、心律失常和心包疾病。

结论

本研究旨在使用 Watchman 装置评估美国人群 pLAAC 术后 30 天的结果。我们的分析表明,十分之一的患者需要再入院。此外,慢性肾脏病、慢性阻塞性肺疾病、心力衰竭和心包疾病与较高的再入院率相关。这些发现将帮助我们评估临床相关性,并预测哪些患者在 Watchman 手术后更有可能再次入院。

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