Research Center of Brain and Cognitive Neuroscience, Liaoning Normal University, Dalian, China; Key Laboratory of Brain and Cognitive Neuroscience, Liaoning Province, Dalian, China.
Qingdao mental health center, Qingdao University, Qingdao, China.
J Affect Disord. 2021 Dec 1;295:284-290. doi: 10.1016/j.jad.2021.08.032. Epub 2021 Aug 27.
Bipolar disorder (BD) has been associated with an increased prevalence of weight gain and abnormally elevated plasma homocysteine (Hcy) levels. However, the relationship between BMI and Hcy in BD patients has not been investigated. This study aimed to explore this relationship in Chinese patients with BD.
Plasma Hcy levels, socio-demographic parameters, clinical and anthropometric data were collected from 195 BD inpatients and 84 healthy controls. The level of plasma Hcy was determined by high-performance liquid chromatography. Body mass index (BMI) was calculated by body weight divided by the square of the height. The participants were divided into a high BMI group and a low BMI group using 24 kg/m as a threshold.
The prevalence of high BMI was slightly elevated in BD patients in comparison to healthy controls. Patients with elevated BMI had significantly higher Hcy levels than patients with low BMI. Hcy level was an independent contributor of the occurrence of high BMI in BD patients. The level of Hcy was positively correlated with BMI in BD patients. In addition, depressive episodes of BD were positively correlated with the prevalence of high BMI and married BD patients were more likely to have high BMI levels.
There is a close relationship between BMI and plasma Hcy levels in patients with BD, suggesting that Hcy may be an important indicator for BD-induced weight gain. This finding provides a new avenue for weight management of BD patients and to help avoid the potential risk of cardiovascular diseases.
双相情感障碍（BD）与体重增加和血浆同型半胱氨酸（Hcy）水平异常升高的患病率增加有关。然而，BD 患者的 BMI 和 Hcy 之间的关系尚未得到研究。本研究旨在探讨中国 BD 患者中这种关系。
从 195 名 BD 住院患者和 84 名健康对照中收集血浆 Hcy 水平、社会人口统计学参数、临床和人体测量数据。采用高效液相色谱法测定血浆 Hcy 水平。体重指数（BMI）通过体重除以身高的平方计算。使用 24 kg/m2 作为阈值将参与者分为高 BMI 组和低 BMI 组。
与健康对照组相比，BD 患者的高 BMI 患病率略有升高。与低 BMI 患者相比，BMI 升高的患者 Hcy 水平显著升高。Hcy 水平是 BD 患者发生高 BMI 的独立因素。Hcy 水平与 BD 患者的 BMI 呈正相关。此外，BD 的抑郁发作与高 BMI 的患病率呈正相关，已婚 BD 患者更有可能出现高 BMI 水平。
BD 患者的 BMI 和血浆 Hcy 水平之间存在密切关系，表明 Hcy 可能是 BD 引起体重增加的重要指标。这一发现为 BD 患者的体重管理提供了新途径，并有助于避免心血管疾病的潜在风险。
