Yuanyuan Zheng, Jianlan Xie, Yanlin Zhang, Xiaoge Zhou
Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China.
Virchows Arch. 2022 May;480(5):1121-1126. doi: 10.1007/s00428-021-03184-5. Epub 2021 Sep 4.
Indolent T-lymphoblastic proliferation (iT-LBP) is the extrathymic proliferation of nonclonal TdT + T cells and is typically associated with lymphoid disorders. Although one study revealed that iT-LBP occurred in angioimmunoblastic T-cell lymphoma, no other lymphoma-related cases have been reported. Here, we report three cases of concurrent iT-LBP and benign or malignant lymphoid disorders. The first patient had bilateral cervical lymph node enlargement, and the resected lymph node showed polyclonal precursor T-cells distributed between benign hyperplastic lymphoid follicles. In the second case, iT-LBP occurred in peripheral T-cell lymphoma with a follicular growth pattern, showing that precursor T-cells were distributed between neoplastic follicles composed of CD4 + and CXCL13 + T-cells. In the third case, polyclonal precursor T-cells were distributed between the neoplastic follicles of follicular lymphoma. In summary, our results indicate an association between iT-LBP and reactive lymphoid hyperplasia (case 1) and lymphoma (cases 2 and 3).
惰性T淋巴细胞增殖（iT-LBP）是胸腺外非克隆性TdT+T细胞的增殖，通常与淋巴系统疾病相关。尽管一项研究显示iT-LBP发生于血管免疫母细胞性T细胞淋巴瘤，但尚未有其他淋巴瘤相关病例的报道。在此，我们报告3例同时发生iT-LBP和良性或恶性淋巴系统疾病的病例。首例患者双侧颈部淋巴结肿大，切除的淋巴结显示多克隆前体T细胞分布于良性增生性淋巴滤泡之间。第二例中，iT-LBP发生于具有滤泡生长模式的外周T细胞淋巴瘤，显示前体T细胞分布于由CD4+和CXCL13+T细胞组成的肿瘤性滤泡之间。第三例中，多克隆前体T细胞分布于滤泡性淋巴瘤的肿瘤性滤泡之间。总之，我们的结果表明iT-LBP与反应性淋巴组织增生（病例1）和淋巴瘤（病例2和3）之间存在关联。
