Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
School of Public Health, Shanghai Jiao Tong University, Shanghai, China.
Alzheimers Dement. 2022 May;18(5):924-933. doi: 10.1002/alz.12436. Epub 2021 Sep 5.
We investigated the association between Alzheimer's disease (AD) and the risk of cancer in the Chinese population.
In this retrospective cohort study, multivariate Cox proportional hazard regression analysis was used to determine the correlation between AD and the risk of various cancers, as shown by hazard ratios (HRs) with 95% confidence intervals (CIs).
Of 8097 AD patients, the HR for all subsequent cancers was 0.822 (95% CI, 0.728-0.928; P = .002). Among them, three specific cancers were associated with AD: lung cancer (HR, 0.656; 95% CI, 0.494- 0.871; P = .004), prostate and testicular cancer (HR, 0.414; 95% CI, 0.202-0.847; P = .016), and lymphoma (HR, 2.202; 95% CI, 1.005-4.826; P = .049).
Patients with AD might have a lower chance of developing several cancers, including lung cancer and prostate and testicular cancer. Meanwhile, a positive association between AD and a higher incident rate of lymphoma was observed.
本研究旨在探讨中国人群中阿尔茨海默病（AD）与癌症风险之间的关联。
本回顾性队列研究采用多变量 Cox 比例风险回归分析，以风险比（HR）及其 95%置信区间（CI）来确定 AD 与各种癌症风险之间的相关性。
在 8097 例 AD 患者中，所有后续癌症的 HR 为 0.822（95%CI，0.728-0.928；P=0.002）。其中，三种特定癌症与 AD 相关：肺癌（HR，0.656；95%CI，0.494-0.871；P=0.004）、前列腺癌和睾丸癌（HR，0.414；95%CI，0.202-0.847；P=0.016）和淋巴瘤（HR，2.202；95%CI，1.005-4.826；P=0.049）。
AD 患者发生多种癌症（包括肺癌和前列腺癌、睾丸癌）的几率可能较低。同时，AD 与淋巴瘤发病率升高之间存在正相关关系。
