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扁桃体切除术对新冠疫情的影响:一项关于发病率和预后的观察性研究

Impact of tonsillectomy on COVID-19 pandemic: an observational study of the incidence and prognosis.

作者信息

Kara Ahmet, Elden Halil, Okur Engin, Yilmaz Mahmut Sinan, Mutlu Fuldem, Guven Mehmet, Demir Deniz

机构信息

Department of Otorhinolaryngology, Sakarya University Faculty of Medicine, Sakarya, Turkey.

Department of Radiology, Sakarya University Faculty of Medicine, Sakarya, Turkey.

出版信息

Acta Otolaryngol. 2021 Sep;141(9):857-859. doi: 10.1080/00016489.2021.1970803. Epub 2021 Sep 5.

DOI:10.1080/00016489.2021.1970803
PMID:34482779
Abstract

BACKGROUND

Due to many different reasons such as possible coronavirus colonization in tonsillar tissue, decreased enzymatic antiviral activity, decreased cytokine activity from palatine tonsil tissue and reduced humoral and cellular immune response, tonsillectomy may alter the incidence of Covid-19.

AIMS/OBJECTIVES: To reveal the frequency of Covid-19 in patients who underwent tonsillectomy and to analyze the effect of tonsillectomy on the severity of the disease.

MATERIALS AND METHODS

Patients aged between 15 and 65 and had a history of tonsillectomy were compared with control group in terms of incidence and severity of Covid-19 disease.

RESULTS

A 4% Covid rRT-PCR test positivity rate was detected in patients with tonsillectomy whereas; it was 6.8% in the control group with a statistically significant difference. However, in terms of disease severity there was no difference between the two groups.

CONCLUSIONS AND SIGNIFICANCE

It has been proven that tonsillectomy surgery does not pose an additional risk in terms of COVID 19 disease severity. The positive effect of tonsillectomy in terms of disease frequency has been even demonstrated for the first time in the literature.

摘要

背景

由于多种不同原因,如扁桃体组织可能存在冠状病毒定植、酶促抗病毒活性降低、腭扁桃体组织细胞因子活性降低以及体液和细胞免疫反应减弱,扁桃体切除术可能会改变新冠病毒疾病(Covid-19)的发病率。

目的

揭示接受扁桃体切除术患者中新冠病毒疾病(Covid-19)的发生率,并分析扁桃体切除术对该疾病严重程度的影响。

材料与方法

将年龄在15至65岁之间且有扁桃体切除术史的患者与对照组在新冠病毒疾病(Covid-19)的发病率和严重程度方面进行比较。

结果

扁桃体切除术患者的新冠病毒逆转录聚合酶链反应(rRT-PCR)检测阳性率为4%,而对照组为6.8%,差异具有统计学意义。然而,在疾病严重程度方面,两组之间没有差异。

结论与意义

已证实扁桃体切除术在新冠病毒疾病(COVID-19)严重程度方面不会带来额外风险。扁桃体切除术在疾病发生率方面的积极作用在文献中首次得到证实。

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Impact of tonsillectomy on COVID-19 pandemic: an observational study of the incidence and prognosis.扁桃体切除术对新冠疫情的影响:一项关于发病率和预后的观察性研究
Acta Otolaryngol. 2021 Sep;141(9):857-859. doi: 10.1080/00016489.2021.1970803. Epub 2021 Sep 5.
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引用本文的文献

1
Surgical removal of tonsils and risk of COVID-19: a nested case-control study using data from UK Biobank and AMORIS Cohort.扁桃体切除术与 COVID-19 风险:基于英国生物银行和 AMORIS 队列数据的巢式病例对照研究。
BMC Med. 2024 Oct 14;22(1):460. doi: 10.1186/s12916-024-03587-6.
2
Treatment of recurrent acute tonsillitis-a systematic review and clinical practice recommendations.复发性急性扁桃体炎的治疗——一项系统评价与临床实践建议
Front Surg. 2023 Oct 10;10:1221932. doi: 10.3389/fsurg.2023.1221932. eCollection 2023.