Fattori Antonin, Arfeuille Gaelle, Parratte Timothée, Gantzer Justine, Olagne Jérôme, Lannes Béatrice, Lhermitte Benoît
Département d'anatomie et de cytologie pathologiques, hôpitaux universitaires de Strasbourg, 67200 Strasbourg, France.
Service de réanimation chirurgicale, hôpitaux universitaires de Strasbourg, 67200 Strasbourg, France.
Ann Pathol. 2021 Nov;41(6):549-553. doi: 10.1016/j.annpat.2021.08.002. Epub 2021 Sep 3.
Ethylene glycol poisoning is relatively rare, with around a hundred cases reported each year in France. Its diagnosis is often challenging and delayed because of a several hours' free interval between ingestion of the toxic and the onset of the first symptoms. Ethylene glycol is a colorless and odorless liquid primarily found in automotive coolants, whose toxicity is linked to its hepatic metabolites. Histologically, ethylene glycol poisoning is characterized by abundant tissular deposits of calcium oxalate crystals. Under polarized light, these crystals appear birefringent and iridescent. Their microscopic appearance and their distribution are pathognomonic of oxalosis. Due to its frequent misleading presentation, the diagnosis of ethylene glycol poisoning is sometimes only made after an autopsy. Hereafter, we report the case of a 59-year-old man diagnosed with ethylene glycol intoxication after a post-mortem histopathological examination of organs.
乙二醇中毒相对罕见，在法国每年报告约100例。由于从摄入毒物到出现首批症状之间有几个小时的无症状间隔期，其诊断往往具有挑战性且会延迟。乙二醇是一种无色无味的液体，主要存在于汽车冷却液中，其毒性与其肝脏代谢产物有关。从组织学上看，乙二醇中毒的特征是草酸钙晶体在组织中大量沉积。在偏振光下，这些晶体呈现双折射且有彩虹色。它们的微观外观及其分布是草酸沉积症的特征性表现。由于其表现常常具有误导性，乙二醇中毒的诊断有时仅在尸检后才能做出。在此，我们报告一例59岁男性病例，该病例是在对器官进行死后组织病理学检查后被诊断为乙二醇中毒。
