Yamagami S, Furutsuka D, Mori K, Kawakita Y
Department of Neuropsychiatry, Osaka City University Medical School, Japan.
Jpn J Psychiatry Neurol. 1987 Sep;41(3):407-10. doi: 10.1111/j.1440-1819.1987.tb01708.x.
Synaptosomal and TCA insoluble proteins were prepared from the cerebral cortices of El(+) during the interictal periods, El(0) which did not stimulate and convulse at all, the seizure-nonsusceptible ddY mice. Both the proteins analyzed by SDS-PAGE electrophoresis indicated 5 major bands and 20-30 minor bands. In the major bands, 67K protein of the synaptosomal and TCA insoluble proteins in the El(+) mice was significantly lower than those of the ddY or El(0) mice and of the ddY mice, respectively.
在发作间期，从完全不引发刺激和惊厥的癫痫不敏感ddY小鼠以及癫痫阳性（El(+)）小鼠的大脑皮层制备突触体蛋白和三羧酸循环（TCA）不溶性蛋白。通过SDS-PAGE电泳分析的这两种蛋白均显示出5条主要条带和20 - 30条次要条带。在主要条带中，El(+)小鼠的突触体蛋白和TCA不溶性蛋白中的67K蛋白分别显著低于ddY小鼠或El(0)小鼠以及ddY小鼠的相应蛋白。
