印度妇产科医师协会关于新冠病毒感染孕妇的全国登记研究初步结果
Preliminary Results from the FOGSI's National Registry on Pregnancy with COVID-19.
作者信息
Gandhi Alpesh Mahendrabhai, Ganatra Atul Morarji, Tank Parikshit
机构信息
Arihant Women's Hospital, Ambica Anandmayi Society, Near Over Bridge, Chandlodiya, Near Manikaka Chawk, Chandlodiya, Ahmedabad, Gujarat 382481 India.
Dr.R.J.Ganatra Nursing Home, Omkar Lal Building, Opposite Mulund West Railway Station, Mulund (West), Mumbai, Maharashtra 400080 India.
出版信息
J Obstet Gynaecol India. 2021 Aug;71(4):361-368. doi: 10.1007/s13224-021-01537-3. Epub 2021 Aug 31.
BACKGROUND/PURPOSE OF THE STUDY: The obstetric population is believed to be more susceptible to adverse consequences of coronavirus disease COVID-19 as compared to the general populace. Clinical characteristics and outcomes data related to COVID-19 infection in obstetric cases are limited and evolving. Most importantly, studies reporting Indian data are strikingly few and of single centre. The objective of our study was thus to address these lacunae using data registered in the FOGSI's National registry on COVID-19 infection in pregnancy (FOGSI COVID registry).
METHODS
We conducted an observational study using data retrieved from the FOGSI COVID registry. Fifty-three hospital departments participating in the registry populated data related to laboratory confirmed and hospitalized COVID-19 obstetric patients. Data for the period of 28 April 2020 to 28 August 2020 were extracted from the registry. A subset of the data was formatted, curated, standardized and harmonized. Descriptive analysis was carried out, and results reported.
RESULTS
Of the 989 cases analyzed, 956 women were pregnant and 33 women were in the postpartum period. A total of 569 women (61.71%, = 922) were multi-gravida, and 713 women (72.98%, = 977) belonged to the 21-30 years age group. A total of 492 cases (52.73%, = 966) had a gestational age > 37 weeks. A total of 754 women (83.41%, = 904) were asymptomatic, and 32 cases (3.54%, = 904) had severe acute respiratory infection (SARI). Fifty-six women (7.19%, = 779) required critical care and ten women (1.01%, = 989) died. A total of 771 pregnant women (97.23%, = 793) gave birth of which 455 cases (59.01%) underwent a lower segment caesarean section (LSCS). There were 749 cases (95.17%, = 771) of live birth that included eight cases of twin deliveries. 195 infants (28.34%, = 688) were admitted to the NICU, and 13 infants (2.99%, = 435) tested COVID-19 positive in the neonatal period. Twelve infants (1.54%, = 779) died.
CONCLUSION
83.41% pregnant women were asymptomatic. COVID-19 infection in obstetric cases from India led to 59.01% LSCS procedures which are lower than many other countries. COVID-19 infection led to a higher maternal mortality and IUFD rate as compared to pregnant women that did not have COVID-19 infection in India. Vertical transmission rate is 2.99% and at par with other countries.
研究背景/目的：与普通人群相比，产科人群被认为更容易受到冠状病毒病COVID-19不良后果的影响。产科病例中与COVID-19感染相关的临床特征和结局数据有限且不断变化。最重要的是，报告印度数据的研究极少且多为单中心研究。因此，我们研究的目的是利用在印度妇产科医师协会（FOGSI）关于妊娠COVID-19感染的国家登记处（FOGSI COVID登记处）登记的数据来填补这些空白。
方法
我们使用从FOGSI COVID登记处检索到的数据进行了一项观察性研究。参与该登记处的53个医院科室提供了与实验室确诊并住院的COVID-19产科患者相关的数据。从登记处提取了2020年4月28日至2020年8月28日期间的数据。对一部分数据进行了格式化、整理、标准化和协调。进行了描述性分析并报告了结果。
结果
在分析的989例病例中,956例为孕妇，33例为产后女性。共有569例女性（61.71%，n = 922）为经产妇，713例女性（72.98%，n = 977）年龄在21 - 30岁之间。共有492例（52.73%，n = 966）孕周>37周。共有754例女性（83.41%，n = 904）无症状，32例（3.54%，n = 904）患有严重急性呼吸道感染（SARI）。56例女性（7.19%，n = 779）需要重症监护，10例女性（1.01%，n = 989）死亡。共有771例孕妇（97.23%，n = 79’）分娩，其中455例（59.01%）接受了低位剖宫产术（LSCS）。有749例（95.17%，n = 771）活产，包括8例双胎分娩。195例婴儿（28.34%，n = 688）入住新生儿重症监护病房（NICU），13例婴儿（2.99%，n = 435）在新生儿期COVID-19检测呈阳性。12例婴儿（1.54%，n = 779）死亡。
结论
83.41%的孕妇无症状。印度产科病例中的COVID-19感染导致59.01%的低位剖宫产术，这一比例低于许多其他国家。与印度未感染COVID-19的孕妇相比，COVID-19感染导致更高的孕产妇死亡率和死胎率。垂直传播率为2.99%，与其他国家相当。
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