Hosseini Maryam Sadat, Hosseini Afsaneh, Ghaffari Elnaz, Radfar Mitra, Shirvani Fariba, Tabatabai Shahrzad, Abtahi Dariush, Mirhadi Mahsa, Mortazavi Maziyar, Ariana Shideh
Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Pediatric Infections Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Educ Health Promot. 2021 May 31;10(1):173. doi: 10.4103/jehp.jehp_20_21. eCollection 2021.
The coronavirus, which is caused by acute respiratory syndrome, appeared in Wuhan, China, in December 2019 and gradually spread around the world until almost all countries became infected with the coronavirus. In Iran, the outbreak of coronavirus began on February 21, 2020, with the report of infection of two people in the city of Qom. The aim of this study is to evaluate the clinical findings of neonates born to pregnant women with corona disease.
During this case study (February 21 to November 30, 2020), out of 88 pregnant mothers who referred to the hospitals of Shahid Beheshti University of Medical Sciences, 44 live neonates were born from 42 pregnant women with COVID-19, who were evaluated for clinical signs by studying their files and reported as a case series, due to limited samples, No statistical analysis of the study was performed.
In studies of clinical records of hospitalized mothers and infants, among the polymerase chain reactions (PCRs) provided for all infants, one PCR was reported positive 2 days after birth, whereas this infant 10 min after birth, immediately after routine procedures, due to positive mother's PCR was isolated from the operating room. However, all of the infant's clinical symptoms were normal during the 3-day hospital stay for routine postpartum care. Twenty-eight days after birth, the baby was reevaluated for clinical, laboratory, and chest X-ray symptoms, all of which were normal. The PCR of other neonates was negative, and five intubated neonates, two twin, and two single died, and the other neonates were discharged. In evaluating the clinical records of mothers of these infants, the mean age is 30 years, and the average gestational age is 35 weeks, 32 cases of caesarean section, and 10 cases of normal delivery.
We describe epidemiological data, demographics, signs and symptoms on admission, laboratory results, comorbidities, infection COVID-19 in the mothers and neonates, chest radiography and computed tomography findings, treatment received for COVID-19, and clinical maternal, fetal, and neonatal outcomes. Due to the fact that the study population is small consist of 42 mothers with COVID-19 infection, among all PCR samples from infants born to COVID-19 positive mothers, the PCR result of one case was positive, and the rest of was negative. Therefore, vertical transmission of COVID-19 through the placenta to the fetus cannot be confirmed or denied, nor can the COVID-19 confirmed or denied the baby's postnatal complication during pregnancy.
由急性呼吸综合征引起的冠状病毒于2019年12月在中国武汉出现，并逐渐在全球传播，直到几乎所有国家都感染了冠状病毒。在伊朗，冠状病毒疫情于2020年2月21日开始，库姆市报告了两人感染。本研究的目的是评估感染新冠疾病的孕妇所分娩新生儿的临床特征。
在本病例研究期间（2020年2月21日至11月30日），在转诊至沙希德·贝赫什提医科大学医院的88名孕妇中，42名感染新冠病毒的孕妇分娩了44名活产新生儿，通过查阅她们的病历对其临床症状进行评估，并作为病例系列报告，由于样本有限，未对该研究进行统计分析。
在对住院母亲和婴儿的临床记录研究中，在为所有婴儿提供的聚合酶链反应（PCR）检测中，有一份PCR检测在出生后2天报告为阳性，而该婴儿在出生后10分钟，在常规程序完成后，因母亲PCR检测呈阳性，立即从手术室被隔离。然而，在为期3天的常规产后护理住院期间，该婴儿的所有临床症状均正常。出生28天后，对该婴儿进行了临床、实验室和胸部X光症状复查，结果均正常。其他新生儿的PCR检测为阴性，5名插管新生儿、2对双胞胎和2名单胎婴儿死亡，其他新生儿出院。在评估这些婴儿母亲的临床记录时，母亲的平均年龄为30岁，平均孕周为35周，剖宫产32例，顺产10例。
我们描述了流行病学数据、人口统计学特征、入院时的体征和症状、实验室检查结果、合并症、母亲和新生儿感染新冠病毒的情况、胸部X线和计算机断层扫描结果、针对新冠病毒的治疗以及母亲、胎儿和新生儿的临床结局。由于研究人群规模较小，仅包括42名感染新冠病毒的母亲，在新冠病毒阳性母亲所生婴儿的所有PCR样本中，一例PCR结果呈阳性，其余均为阴性。因此，无法证实或否认新冠病毒通过胎盘垂直传播给胎儿，也无法证实或否认新冠病毒与婴儿孕期产后并发症之间的关系。
