Khan Abbas, Mubarik Sumaira, Nabi Ghulam, Fan Cuifang, Wang Suqing
Department of Preventive Medicine, School of Health Sciences, Wuhan University, Wuhan, Hubei, China.
Department of Dietetics and Nutritional Sciences, University of Sialkot, Pakistan.
J Res Med Sci. 2021 Jun 30;26:38. doi: 10.4103/jrms.JRMS_131_19. eCollection 2021.
Preeclampsia (PE) and premature rupture of membrane (PROM) are considered significant risk factors for lower neonatal birth weight and birth length. However, very limited studies have reported the impact of PE and PROM on neonatal birth weight and birth length by gestational week. Therefore, we aimed to determine the effect of PE and PROM on neonatal birth weight and length by gestational age.
A total of 9707 singleton neonates were selected for this study. All the data were collected and documented in the obstetric register by the trained nurses in the Gynecology and Obstetrics Department.
The neonatal mean birth weights and birth lengths were statistically significantly ( < 0.05) lowered among preeclamptic mothers compared to mothers without PE throughout the gestational age. Statistically significantly ( < 0.05) lowered mean birth weights and birth lengths were found among neonates born to mothers with PROM than among neonates born to mothers without PROM by all gestational weeks except for 32 weeks and 36 weeks. Moreover, in a multiple linear regression model, PE and PROM were significantly negatively associated with neonatal birth weights and birth lengths by almost all gestational weeks (β <0, < 0.05).
We concluded that after adjustment for covariates and confounding factors, PE and PROM had a significantly negative association with neonatal birth weights and birth lengths by all gestational weeks.
子痫前期（PE）和胎膜早破（PROM）被认为是导致新生儿出生体重降低和身长缩短的重要风险因素。然而，关于PE和PROM对不同孕周新生儿出生体重和身长影响的研究非常有限。因此，我们旨在确定PE和PROM对不同孕周新生儿出生体重和身长的影响。
本研究共纳入9707例单胎新生儿。所有数据均由妇产科经过培训的护士收集并记录在产科登记册中。
在整个孕周内，与未患子痫前期的母亲相比，子痫前期母亲所生新生儿的平均出生体重和身长在统计学上显著降低（P<0.05）。除32周和36周外，在所有孕周中，胎膜早破母亲所生新生儿的平均出生体重和身长在统计学上均显著低于未发生胎膜早破母亲所生新生儿。此外，在多元线性回归模型中，几乎在所有孕周，PE和PROM与新生儿出生体重和身长均呈显著负相关（β<0，P<0.05）。
我们得出结论，在调整协变量和混杂因素后，PE和PROM在所有孕周均与新生儿出生体重和身长呈显著负相关。
