Pak J Biol Sci. 2021 Jan;24(7):733-740. doi: 10.3923/pjbs.2021.733.740.
<b>Background and Objective:</b> Cardiovascular Diseases (CVDs) remain the main cause of mortality globally. High cholesterol levels (hypercholesterolemia) and high blood glucose (diabetes) are among the factors that increase the risk for CVDs. Application of inhibitors for the digestive enzymes accountable for the macronutrient hydrolysis, such as carbohydrates and fats, is one of the prevalent approaches in the development of medications against CVDs. The present study was performed to examine, <i>in vitro</i>, the lipase and amylase inhibitory potential of phenolic rich extract of leaves of four date palm cultivars. <b>Materials and Methods:</b> In the current study, the research investigated the potentiality of phytochemicals extracted from leaves of four date palm cultivars (Rawthan, Rabeaa, Barny and Ajwa), collected from Al-Madinah Governorate as lipase and amylase inhibitors and as antioxidants. Moreover, the total contents of flavonoids and phenolics were assessed. <b>Results:</b> The results revealed that all the tested cultivars showed promising lipase and amylase inhibition and antioxidants capacities. However, Rawthan and Ajwa were the most powerful cultivars. <b>Conclusion:</b> Therefore, the results presented herein suggest as the earliest report, the potential use of date palm leaves as a potential source for lipase and amylase inhibitors as an approach to decrease the risk for CVDs.
心血管疾病（CVDs）仍然是全球主要的死亡原因。高胆固醇水平（高胆固醇血症）和高血糖（糖尿病）是增加 CVDs 风险的因素之一。应用负责水解宏量营养素（如碳水化合物和脂肪）的消化酶抑制剂是开发 CVDs 治疗药物的一种常见方法。本研究旨在体外研究四种椰枣品种叶片中富含酚类的提取物对脂肪酶和淀粉酶的抑制潜力。材料与方法：在本研究中，研究了从 Al-Madinah 省采集的四种椰枣品种（Rawthan、Rabeaa、Barny 和 Ajwa）叶片中提取的植物化学物质作为脂肪酶和淀粉酶抑制剂以及抗氧化剂的潜力。此外，还评估了类黄酮和总酚的含量。结果：结果表明，所有测试的品种都表现出有希望的脂肪酶和淀粉酶抑制作用和抗氧化能力。然而，Rawthan 和 Ajwa 是最强大的品种。结论：因此，本文的研究结果表明，椰枣叶可能作为一种潜在的脂肪酶和淀粉酶抑制剂的来源，用于降低 CVDs 的风险。
