Department of Chemistry, Laboratory of Catalysis and Organic Synthesis, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand, India.
Chem Commun (Camb). 2021 Sep 28;57(77):9807-9819. doi: 10.1039/d1cc03404a.
(1,) annulation reactions using (de)-hydrogenative coupling with alcohols or diols represent a straightforward technique for the synthesis of cyclic moieties. Utilization of such renewable resources for chemical transformations in a one-pot manner is the main focus, which avoids generation of stoichiometric waste. Application of such (1,) annulation approaches drives the catalysis research in a more sustainable way and generates dihydrogen and water as by-products. This feature article highlights the recent (from 2015 to March 2021) progress in the synthesis of stereo-selective cycloalkanes and cycloalkenes, saturated and unsaturated N-heterocycles (cyclic amine, imide, lactam, tetrahydro β-carboline, quinazoline, quinazolinone, 1,3,5-triazines ) and other N-heterocycles with the formation of multiple bonds in a one pot operation. Mechanistic studies, new catalytic approaches, and synthetic applications including drug synthesis and post-drug derivatization, scope, and limitations are discussed.
（1），使用（脱氢）偶联醇或二醇的环化反应是合成环状部分的一种直接技术。以一锅法的方式利用这些可再生资源进行化学转化是主要关注点，这避免了产生化学计量的废物。这种（1），环化方法的应用推动了更可持续的催化研究，并产生氢气和水作为副产物。本文重点介绍了 2015 年至 2021 年 3 月间在立体选择性环烷烃和环烯烃、饱和和不饱和 N-杂环（环状胺、酰亚胺、内酰胺、四氢 β-咔啉、喹唑啉、喹唑啉酮、1,3,5-三嗪）以及其他 N-杂环中形成多个键的合成方面的最新进展一锅操作。讨论了机理研究、新的催化方法以及包括药物合成和药物后衍生化在内的合成应用、范围和局限性。
