沙特阿拉伯中轴型脊柱关节炎临床特征的横断面研究：初步结果。

A cross-sectional study on clinical characteristics of Saudi axial spondylarthritis: preliminary results.

机构信息

Department of Medicine, College of Medicine, Rheumatology Unit, King Saud, University, Riyadh, Saudi Arabia.

出版信息

Eur Rev Med Pharmacol Sci. 2021 Aug;25(16):5241-5247. doi: 10.26355/eurrev_202108_26538.

DOI:10.26355/eurrev_202108_26538

PMID:34486699

Abstract

OBJECTIVE

To describe Spondyloarthritis (SpA) patients in a single center (preliminary phase), Build connections to establish local cohorts, Saudi Registry, and publication in Gulf and Arab database.

PATIENTS AND METHODS

This prospective observational cohort consists of patients with spondylarthritis (SpA) diagnosed by a rheumatologist. Patients with AS were defined as those who met the modified New York criteria for Ankylosing Spondylitis (AS) 1984. All other patients with axial SpA who did not meet the radiology criteria of modified New York criteria for Ankylosing Spondylitis were classified as having non-radiographic axial SpA based on Assessment of SpondyloArthritis International Society (ASAS) diagnostic criteria for axial spondyloarthropathy.

RESULTS

The study group comprised 106 patients with SpA (49 patients with AS and 57 patients with non-radiographic axial SpA). Patients with non-radiographic axial SpA and patients with AS who had previously been treated with biologic disease-modifying drugs (DMARDs) were 66.67 percent and 83.67 percent, respectively. In patients with AS, CRP and age significantly impact disease activities (p<0.05). The overall mean ASDAS score was 2.3 ± 0.7.

CONCLUSIONS

This study has shown a more detailed description of the largest Saudi cohort reported yet. Interestingly, both disease groups, Ankylosing spondylitis and non-radiographic spondyloarthritis showed a lower prevalence of HLA-B27 is lower in the general Saudi population compared to other nations including Caucasians, thus, limiting its use as a diagnostic tool. The majority of both groups, nearly three-quarters of all patients (74.53%) in biologic DMARD treatment, and only (22.64%) used csDMARD treatment, which may help control disease activity and showing easier access and availability of these therapies to the patient. Patients with non-radiographic axial SpA showed slightly higher Extra-articular Manifestations comparing with AS patients.

摘要

目的

描述单中心（初步阶段）的脊柱关节炎（SpA）患者，建立联系以建立当地队列、沙特登记处，并在海湾和阿拉伯数据库发表。

患者和方法

这项前瞻性观察性队列研究包括由风湿病学家诊断为脊柱关节炎（SpA）的患者。符合改良纽约标准的 AS 患者被定义为符合 1984 年强直性脊柱炎（AS）改良纽约标准的患者。所有其他不符合改良纽约标准的 AS 放射学标准的轴向 SpA 患者，根据评估脊柱关节炎国际协会（ASAS）的轴向脊柱关节炎诊断标准，被归类为非放射性轴向 SpA。

结果

研究组包括 106 例 SpA 患者（49 例 AS 和 57 例非放射性轴向 SpA）。非放射性轴向 SpA 患者和之前接受过生物疾病修饰药物（DMARDs）治疗的 AS 患者分别为 66.67%和 83.67%。在 AS 患者中，CRP 和年龄对疾病活动有显著影响（p<0.05）。总体平均 ASDAS 评分 2.3±0.7。

结论

本研究展示了迄今为止沙特最大队列的更详细描述。有趣的是，与包括白种人在内的其他国家相比，非放射性脊柱关节炎和强直性脊柱炎这两个疾病组的 HLA-B27 阳性率均较低，因此限制了其作为诊断工具的应用。两组中大多数患者（74.53%）接受生物 DMARD 治疗，近四分之三（74.53%）接受生物 DMARD 治疗，只有（22.64%）接受 csDMARD 治疗，这可能有助于控制疾病活动，并显示出这些治疗方法更容易为患者获得和应用。与 AS 患者相比，非放射性轴向 SpA 患者的关节外表现略高。