Department of Public Health, Section of General Practice and Research Unit for General Practice, University of Copenhagen, Copenhagen, Denmark.
Department of Clinical Microbiology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark.
Eur J Gen Pract. 2021 Dec;27(1):257-263. doi: 10.1080/13814788.2021.1965121.
To curb future antibiotic resistance it is important to monitor and investigate current prescription patterns of antibiotics.
To examine trends in antibiotic prescription to children aged 0-6 years old and the association with socioeconomic status of municipalities in the Capital region of Denmark between 2009 and 2018.
This is a register-based study combining data on antibiotic treatments from 2009 to 2018, inhabitant-data and socioeconomic municipality scores. Subjects were children aged 0-6 years, residing in the Capital Region of Denmark. The study quantifies the use of antibiotics as number of antibiotic treatments/1000 inhabitants/year (TIY), inhabitants defined as children aged 0-6. Socioeconomic status of the municipalities is evaluated by a score from 3 to 12.
The average TIY of the municipalities decreased from 741.2 [95%CI 689.3-793.2] in 2009 to 348.9 [329.4-368.4] in 2018. The difference between the highest and lowest prescribing municipalities was reduced from 648.3 TIY in 2009-212.5 TIY in 2018. The average increase in TIY per unit increase in socioeconomic municipality score changed from 20.05 [7.69-31.06] in 2009 to -4.58 [-16.02-5.60] in 2018, representing a decreasing association between socioeconomic municipality score and use of antibiotic in the respective municipalities.
The trend in antibiotic prescription to children aged 0-6 years old decreased substantially in all the investigated municipalities in the 10-year study period. Local differences in prescription rates declined towards a more uniform prescription pattern across municipalities and association with socioeconomic status of the municipalities was reduced.
为了遏制未来的抗生素耐药性，监测和调查当前抗生素的处方模式非常重要。
检查丹麦首都地区 2009 年至 2018 年 0-6 岁儿童抗生素处方的趋势，以及与市政当局社会经济地位的关联。
这是一项基于登记的研究，结合了 2009 年至 2018 年抗生素治疗的数据、居民数据和社会经济市政评分。研究对象为 0-6 岁的儿童，居住在丹麦首都地区。该研究通过每 1000 名居民/年的抗生素治疗数量（TIY）来量化抗生素的使用情况，居民定义为 0-6 岁的儿童。通过 3 至 12 分的评分来评估市政当局的社会经济地位。
市政当局的平均 TIY 从 2009 年的 741.2 [95%CI 689.3-793.2] 降至 2018 年的 348.9 [329.4-368.4]。处方最多和最少的市政当局之间的差异从 2009 年的 648.3 TIY 缩小到 2018 年的 212.5 TIY。社会经济市政评分每增加一个单位，TIY 的平均增长率从 2009 年的 20.05 [7.69-31.06] 变为 2018 年的-4.58 [-16.02-5.60]，这表明社会经济市政评分与各自市政当局抗生素使用之间的关联呈下降趋势。
在这项为期 10 年的研究中，所有研究的 0-6 岁儿童的抗生素处方趋势都大幅下降。处方率的地方差异朝着各市政当局更统一的处方模式缩小，与市政当局社会经济地位的关联也减少了。
