Department of Physiatry, Children's Healthcare of Atlanta, Johnson Ferry Rd NE. Atlanta, GA, USA.
J Pediatr Rehabil Med. 2021;14(3):333-343. doi: 10.3233/PRM-200677.
Anti-N-Methyl-D-Aspartate Receptor Encephalitis (ANMDARE) is one of the most common autoimmune encephalitis in the pediatric population. Patients with ANMDARE initially present with a prodrome of neuropsychiatric symptoms followed by progressively worsening seizures, agitation, and movement disorders. Complications can include problems such as aggression, insomnia, catatonia, and autonomic instability. Due to the complexity of this disease process, symptom management can be complex and may lead to significant polypharmacy. The goal of this review is to educate clinicians about the challenges of managing this disorder and providing guidance in symptom management.
抗 N-甲基-D-天冬氨酸受体脑炎（Anti-N-Methyl-D-Aspartate Receptor Encephalitis，ANMDARE）是儿科人群中最常见的自身免疫性脑炎之一。ANMDARE 患者最初表现为神经精神症状前驱期，随后逐渐出现癫痫发作、激越和运动障碍。并发症可包括攻击行为、失眠、紧张症和自主神经不稳定等问题。由于该疾病过程的复杂性，症状管理可能较为复杂，并可能导致使用多种药物。本综述的目的是教育临床医生了解管理这种疾病的挑战，并提供症状管理方面的指导。
