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Live-Cell Imaging of Guanosine Tetra- and Pentaphosphate (p)ppGpp with RNA-based Fluorescent Sensors*.
Angew Chem Int Ed Engl. 2021 Nov 2;60(45):24070-24074. doi: 10.1002/anie.202111170. Epub 2021 Oct 5.
2
Guanosine tetra- and pentaphosphate increase antibiotic tolerance by reducing reactive oxygen species production in .
J Biol Chem. 2018 Apr 13;293(15):5679-5694. doi: 10.1074/jbc.RA117.000383. Epub 2018 Feb 23.
4
Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone.
Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13348-53. doi: 10.1073/pnas.1505271112. Epub 2015 Oct 12.
5
Crucial Role of ppGpp in the Resilience of Escherichia coli to Growth Disruption.
mSphere. 2020 Dec 23;5(6):e01132-20. doi: 10.1128/mSphere.01132-20.
6
Differential binding of ppGpp and pppGpp to E. coli RNA polymerase: photo-labeling and mass spectral studies.
Genes Cells. 2015 Dec;20(12):1006-16. doi: 10.1111/gtc.12304. Epub 2015 Oct 8.
7
Guanosine tetra- and pentaphosphate promote accumulation of inorganic polyphosphate in Escherichia coli.
J Biol Chem. 1997 Aug 22;272(34):21240-3. doi: 10.1074/jbc.272.34.21240.
10
Sound the (Smaller) Alarm: The Triphosphate Magic Spot Nucleotide pGpp.
Infect Immun. 2023 Apr 18;91(4):e0043222. doi: 10.1128/iai.00432-22. Epub 2023 Mar 15.

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Visualizing intracellular glycine with two-dye and single-dye ratiometric RNA-based sensors.
Nucleic Acids Res. 2025 Sep 5;53(17). doi: 10.1093/nar/gkaf839.
2
Analysis of (p)ppGpp metabolism and signaling using a dynamic luminescent reporter.
PLoS Genet. 2025 Aug 22;21(8):e1011691. doi: 10.1371/journal.pgen.1011691. eCollection 2025 Aug.
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Disrupting NtrC function reveals unexpected robustness in a central cell cycle regulatory network.
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Bioenergetic stress potentiates antimicrobial resistance and persistence.
Nat Commun. 2025 Jun 9;16(1):5111. doi: 10.1038/s41467-025-60302-6.
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How to quantify magic spots - a brief overview of (p)ppGpp detection and quantitation methods.
Front Mol Biosci. 2025 Mar 25;12:1574135. doi: 10.3389/fmolb.2025.1574135. eCollection 2025.
6
Genetically Encoded Fluorogenic DNA Aptamers for Imaging Metabolite in Living Cells.
J Am Chem Soc. 2025 Jan 15;147(2):1529-1541. doi: 10.1021/jacs.4c09855. Epub 2024 Dec 31.
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A Small-Molecule Approach Enables RNA Aptamers to Function as Sensors for Reactive Inorganic Targets.
Angew Chem Int Ed Engl. 2025 Mar 17;64(12):e202421936. doi: 10.1002/anie.202421936. Epub 2024 Dec 20.
8
Fluorogenic RNA-Based Biosensors of Small Molecules: Current Developments, Uses, and Perspectives.
Biosensors (Basel). 2024 Aug 1;14(8):376. doi: 10.3390/bios14080376.
9
Multiplexed sequential imaging in living cells with orthogonal fluorogenic RNA aptamer/dye pairs.
Nucleic Acids Res. 2024 Aug 27;52(15):e67. doi: 10.1093/nar/gkae551.
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Genetically encoded RNA-based sensors with Pepper fluorogenic aptamer.
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本文引用的文献

2
Genetically Encoded Ratiometric RNA-Based Sensors for Quantitative Imaging of Small Molecules in Living Cells.
Angew Chem Int Ed Engl. 2019 Dec 9;58(50):18271-18275. doi: 10.1002/anie.201911799. Epub 2019 Oct 24.
3
Optimised Synthesis of the Bacterial Magic Spot (p)ppGpp Chemosensor PyDPA.
Chembiochem. 2019 Jul 1;20(13):1717-1721. doi: 10.1002/cbic.201900013. Epub 2019 May 24.
4
Transcriptional Responses to ppGpp and DksA.
Annu Rev Microbiol. 2018 Sep 8;72:163-184. doi: 10.1146/annurev-micro-090817-062444.
5
ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands.
Nat Chem Biol. 2018 Sep;14(9):887-894. doi: 10.1038/s41589-018-0114-4. Epub 2018 Aug 17.
6
Absolute Quantification of ppGpp and pppGpp by Double-Spike Isotope Dilution Ion Chromatography-High-Resolution Mass Spectrometry.
Anal Chem. 2018 Sep 18;90(18):10715-10723. doi: 10.1021/acs.analchem.8b00829. Epub 2018 Sep 4.
8
Riboswitches for the alarmone ppGpp expand the collection of RNA-based signaling systems.
Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):6052-6057. doi: 10.1073/pnas.1720406115. Epub 2018 May 21.
10
Terbium(III) Modified Fluorescent Carbon Dots for Highly Selective and Sensitive Ratiometry of Stringent.
Anal Chem. 2018 Mar 20;90(6):4003-4009. doi: 10.1021/acs.analchem.7b05149. Epub 2018 Mar 7.

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