Department of Pharmaceutical Sciences & Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, India.
Department of Pharmacology, Central University of Punjab, Ghudda, Bathinda, India.
Brain Inj. 2021 Aug 24;35(10):1113-1120. doi: 10.1080/02699052.2021.1972152. Epub 2021 Sep 6.
Traumatic brain injury (TBI) involves structural damage to the brain regions causing death or disability in patients with lifelong sufferings. Accidental injuries to the brain, besides structural damage, if any, cause activation of various deleterious pathways leading to subsequent neuronal death and permanent dysfunction. However, immediate medical management/treatments could reduce the chances of disability and suffering to the patients. The objective of the current review is to review triggered molecular pathways following TBI and discuss possible targets that could restore brain functions. Understanding the pathologic process is always useful to device novel treatment strategies and may rescue the patient with TBI from death or associated co-morbidities. The current review significantly contributes to improve our understanding about the molecular pathways and neuronal death following TBI and helps us to provide possible targets that could be useful in the management/treatment of TBI.
创伤性脑损伤（TBI）涉及脑区域的结构损伤，导致患者终身遭受死亡或残疾。脑的意外损伤，除了任何结构损伤外，还会引发各种有害途径的激活，导致随后的神经元死亡和永久性功能障碍。然而，及时的医疗管理/治疗可以降低患者残疾和痛苦的几率。本综述的目的是回顾 TBI 后触发的分子途径，并讨论可能恢复脑功能的目标。了解病理过程总是有助于设计新的治疗策略，并可能使 TBI 患者免于死亡或相关合并症。本综述极大地有助于提高我们对 TBI 后分子途径和神经元死亡的理解，并帮助我们提供可能有用的治疗 TBI 的目标。
