Kuopio Musculoskeletal Research Unit (KMRU), Surgery, Institute of Clinical Medicine, University of Eastern Finland (UEF), Kuopio, Finland.
Kuopio Musculoskeletal Research Unit (KMRU), Surgery, Institute of Clinical Medicine, University of Eastern Finland (UEF), Kuopio, Finland.
J Clin Epidemiol. 2021 Dec;140:44-55. doi: 10.1016/j.jclinepi.2021.08.032. Epub 2021 Sep 3.
To investigate sociodemographic characteristics and physical and mental health indicators between participants and nonparticipants of a large-scale 2-year exercise RCT including noninvited women living in nearby rural area in Finland.
From a previous OSTPRE study cohort, 914 women (aged 72-84) participated in Kuopio Fall Prevention Study in 2016-2019. The participants were compared to non-participants (n = 4,536) and noninvited OSTPRE women (n = 7,119) living outside the urban recruitment area.
Participants were younger (P< 0.001) with higher education (P< 0.001) and had more often regular hobbies (P< 0.001) and physical exercising (P< 0.001) than nonparticipants or noninvited. They reported better functional capability (P< 0.001), mental (P< 0.001) and subjective health (P< 0.001), lower number of medications (P< 0.001), less fear of falls (P< 0.001), but more frequent falls (P= 0.002) and more often musculoskeletal diseases (P= 0.006). Participants also showed better functional capacity in the clinical measurements. In register analysis, urban-rural differences in the prevalence of diseases were detected.
In population-based exercise interventions, participants are more likely to be better off in respect to physical and mental wellbeing, functional capability and sociodemographic status. Recruiting participants only from cities increases unavoidable selection bias due to urban-rural differences which should be noticed when interpreting and generalizing RCT results.
ClinicalTrials.gov identifier NCT02665169.
调查一项大型为期 2 年的锻炼随机对照试验（RCT）参与者与非参与者的社会人口统计学特征以及身心健康指标，该试验包括芬兰附近农村地区未受邀的女性。
在之前的 OSTPRE 研究队列中，914 名（年龄 72-84 岁）女性参加了 2016-2019 年的库奥皮奥防跌倒研究。将参与者与非参与者（n=4536）和居住在城市招募区域外的未受邀的 OSTPRE 女性（n=7119）进行比较。
与非参与者或未受邀者相比，参与者更年轻（P<0.001），受教育程度更高（P<0.001），更经常有定期的爱好（P<0.001）和体育锻炼（P<0.001）。他们报告了更好的功能能力（P<0.001）、心理（P<0.001）和主观健康（P<0.001）、更少的药物使用（P<0.001）、更少的跌倒恐惧（P<0.001），但跌倒更频繁（P=0.002）和更常见的肌肉骨骼疾病（P=0.006）。参与者在临床测量中也表现出更好的功能能力。在登记分析中，检测到城乡疾病患病率的差异。
在基于人群的锻炼干预中，参与者在身心健康、功能能力和社会人口统计学地位方面更有可能受益。仅从城市招募参与者会因城乡差异而导致不可避免的选择偏倚，在解释和推广 RCT 结果时应注意这一点。
ClinicalTrials.gov 标识符 NCT02665169。
