Department of Oral Mucosal disease, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; National Clinical Research Center for Oral Diseases, Shanghai 200011, China; Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.
Department of Oral Mucosal disease, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China; National Center for Stomatology, Shanghai 200011, China.
Photodiagnosis Photodyn Ther. 2021 Dec;36:102523. doi: 10.1016/j.pdpdt.2021.102523. Epub 2021 Sep 4.
Ablative fractional laser-assisted photodynamic therapy (AFL-PDT) is explored as an effective method in some premalignant diseases, whereas the effect of AFL-PDT on oral leukoplakia (OL), the best-known precursor of oral squamous cell carcinoma, remains undetermined.
Forty-eight patients, histologically diagnosed with OL, were randomized (1:1) to receive either AFL-PDT or ablative fractional laser (AFL) treatment. All patients were followed up at 1, 3, 6 and 12 months postoperatively. The primary endpoints of efficacy and clinical recurrence and the secondary endpoint of side effects were assessed.
Forty-four patients completed the study. The 100% effective cure rate in the AFL-PDT group was higher than that in AFL group (80.9%, P<0.05) with 19.1% difference (95%CI: 0.7-40.0%). Compared to AFL group, recurrence observed at 6 and 12 months post-treatment tended to occur in fewer patients in the AFL-PDT group (P<0.05). No severe adverse events or systemic side effects were observed in either group.
AFL-PDT may effectively reduce recurrence of OL with high clinical efficacy and good tolerability, suggesting it may be a promising treatment for OL.
光消融术辅助光动力疗法（AFL-PDT）在某些癌前病变中被探索为一种有效方法，而光消融术对口腔白斑病（OL）的疗效，OL 是口腔鳞状细胞癌最著名的前体，仍不确定。
48 例经组织学诊断为 OL 的患者被随机（1:1）分为 AFL-PDT 或光消融术（AFL）治疗组。所有患者均在术后 1、3、6 和 12 个月进行随访。评估疗效和临床复发的主要终点以及不良反应的次要终点。
44 例患者完成了研究。AFL-PDT 组的 100%有效治愈率高于 AFL 组（80.9%，P<0.05），差异为 19.1%（95%CI：0.7-40.0%）。与 AFL 组相比，AFL-PDT 组在治疗后 6 个月和 12 个月观察到的复发患者人数较少（P<0.05）。两组均未观察到严重不良事件或全身不良反应。
AFL-PDT 可能有效降低 OL 的复发率，具有较高的临床疗效和良好的耐受性，表明其可能是 OL 的一种有前途的治疗方法。
