BRCA 突变型胰腺癌维持奥拉帕利治疗时发生的不常见转移：两例病例报告并文献复习。
Unusual metastasis in BRCA mutated pancreatic cancer while on maintenance Olaparib: Two case reports and review of the literature.
机构信息
Departement of Medical Oncolgy, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
出版信息
Eur J Cancer. 2021 Nov;157:63-67. doi: 10.1016/j.ejca.2021.07.042. Epub 2021 Sep 4.
The most common metastatic sites of pancreatic cancer are the liver, lymph nodes, peritoneum and lung. Here we report two cases of BRCA mutated pancreatic cancer that developed unusual metastasis while treatment with maintenance Olaparib and leading to rapid death. We hereby review the literature and address the possibility of a different nature and tumour biology of BRCA mutated cancer treated with PARP inhibitors.
胰腺癌最常见的转移部位是肝脏、淋巴结、腹膜和肺。在这里，我们报告了两例携带 BRCA 突变的胰腺癌病例，在接受奥拉帕利维持治疗时出现了不常见的转移，并导致迅速死亡。我们在此回顾文献，并探讨了接受 PARP 抑制剂治疗的 BRCA 突变型癌症是否具有不同的性质和肿瘤生物学。
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