Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
J Perinatol. 2021 Oct;41(10):2544-2548. doi: 10.1038/s41372-021-01202-7. Epub 2021 Sep 6.
To determine the etiology and outcome of non-immune hydrops fetalis (NIHF) according to gestational age at diagnosis and intrauterine treatment.
A total of 122 NIHF cases were included. Medical records and ultrasonographic images were reviewed. The etiology, outcome, and intrauterine treatment were assessed.
The etiology was determined in 100 cases, and Hb Bart's disease was the most common. Two cases each of homozygous Southeast Asian ovalocytosis (SAO) and hemoglobin Constant Spring (Hb CS) were found. NIHF diagnosed in early gestation (<24 weeks) had a higher rate of chromosomal abnormalities and fetal demise. Intrauterine treatment was given in 18 cases, and 50% had successful live births.
Hb Bart's disease was the most common cause of NIHF. SAO and Hb CS were associated with hydrops. NIHF in gestational age <24 weeks was associated with chromosomal abnormalities and fetal demise. Intrauterine treatment should be offered in selected cases.
根据诊断时的孕周和宫内治疗情况，确定非免疫性胎儿水肿（NIHF）的病因和结局。
共纳入 122 例 NIHF 病例。回顾了病历和超声图像。评估了病因、结局和宫内治疗。
在 100 例病例中确定了病因，最常见的是 Hb Bart's 病。还发现了各 2 例纯合型东南亚卵形红细胞增多症（SAO）和血红蛋白 Constant Spring（Hb CS）。<24 孕周诊断的 NIHF 染色体异常和胎儿死亡的发生率更高。18 例进行了宫内治疗，50%成功活产。
Hb Bart's 病是 NIHF 最常见的病因。SAO 和 Hb CS 与水肿有关。<24 孕周的 NIHF 与染色体异常和胎儿死亡有关。应在选定的病例中提供宫内治疗。
