Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Endocrinol (Lausanne). 2021 Aug 18;12:655803. doi: 10.3389/fendo.2021.655803. eCollection 2021.
Some studies have demonstrated that adenomyosis patients can achieve a comparable pregnancy outcome with women with normal uteruses, while there is no unanimous conclusion at present.
We recruited 65 adenomyosis patients and 260 frequency-matched control women with endometriosis at a ratio of 1:4 according to age. Clinical pregnancy rate, spontaneous abortion rate, and live birth rate were compared between these two groups after controlling other factors.
Compared with endometriosis patients, adenomyosis patients had a higher antral follicle count (AFC) (12.71 11.65, =0.027). Though the two groups had the same number of embryos transferred, adenomyosis patients had an obviously declined implantation rate (31.91% 46.74%, =0.005), clinical pregnancy rate (47.06% 64.42%, P=0.028), live birth rate (31.37% 54.81%, P=0.004), and significantly increased spontaneous abortion rate (33.33% 13.43%, P=0.034). Multivariate logistic regression analysis showed that adenomyosis had adverse influences on pregnancy outcome when age and the number of embryo transfers were controlled (adjusted OR=0.361, P=0.003).
Even after being matched with age, adenomyosis still had adverse influences on the pregnancy outcome of IVF in patients undergoing the long protocol.
一些研究表明，子宫腺肌病患者可以获得与正常子宫妇女相当的妊娠结局，尽管目前尚无一致的结论。
我们按照 1:4 的年龄比例，招募了 65 名子宫腺肌病患者和 260 名子宫内膜异位症患者作为对照组。在控制其他因素后，比较两组的临床妊娠率、自然流产率和活产率。
与子宫内膜异位症患者相比，子宫腺肌病患者的窦卵泡数（AFC）更高（12.71±11.65，=0.027）。尽管两组移植胚胎数量相同，但子宫腺肌病患者的种植率明显下降（31.91% vs. 46.74%，=0.005），临床妊娠率（47.06% vs. 64.42%，P=0.028）、活产率（31.37% vs. 54.81%，P=0.004）降低，自然流产率升高（33.33% vs. 13.43%，P=0.034）。多因素 logistic 回归分析显示，在控制年龄和胚胎移植数量后，子宫腺肌病对长方案 IVF 妊娠结局有不良影响（调整 OR=0.361，P=0.003）。
即使在年龄匹配的情况下，子宫腺肌病仍对长方案 IVF 妊娠结局有不良影响。
