Key Lab of Biobased Polymer Materials of Shandong Provincial Education Department, College of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China.
National Engineering Laboratory of Medical Implantable Devices & Key Laboratory for Medical Implantable Devices of Shandong Province, WEGO Holding Company Limited, Weihai 264210, P. R. China.
J Mater Chem B. 2021 Oct 6;9(38):8074-8080. doi: 10.1039/d1tb01271a.
Dermal substitutes are indispensable for repairing large full-thickness skin defects. Only a few biomaterials for dermal substitution have been put into clinical practice. Therefore, novel artificial dermal substitutes that can meet clinical requirements are in urgent need. Biodegradable poly(4-hydroxybutyrate) (P4HB), which has been approved by the U.S. FDA, can be considered as a possible alternative biomaterial to construct dermal substitutes. In this work, three-dimensional P4HB fibrous membranes were constructed by an electrospinning technique. These P4HB fibrous membranes showed excellent air-permeability, and better water uptake capacity compared to P4HB strip and polycaprolactone (PCL) fibrous membrane controls. The hemocompatibility and cytotoxicity of P4HB fibrous membranes were investigated. Sprague-Dawley (SD) rat model studies revealed that P4HB fibrous membranes can be used as artificial dermis to improve wound healing for full-thickness skin defects.
皮肤替代物对于修复大面积全层皮肤缺损是不可或缺的。只有少数几种用于皮肤替代的生物材料被应用于临床实践。因此，急需新型的、能满足临床需求的人工皮肤替代物。已被美国 FDA 批准的可生物降解的聚 4-羟基丁酸酯（P4HB），可被视为构建皮肤替代物的一种可能的替代生物材料。在这项工作中，通过静电纺丝技术构建了三维 P4HB 纤维膜。与 P4HB 条和聚己内酯（PCL）纤维膜对照相比，这些 P4HB 纤维膜具有优异的透气性和更好的吸水性。研究了 P4HB 纤维膜的血液相容性和细胞毒性。Sprague-Dawley（SD）大鼠模型研究表明，P4HB 纤维膜可用作人工真皮，以改善全层皮肤缺损的伤口愈合。
