体质指数或代谢综合征成分导致女性抑郁的作用：减肥临床试验的观察结果。

The role of body mass index or metabolic syndrome components causing depression in women: An observation from weight reduction clinical trial.

机构信息

Department of Pharmacy Practice, Vignan Pharmacy College, Guntur, 522213, India.

Department of Endocrinology and Metabolism, Endo-life Speciality Hospital, Guntur, India.

出版信息

J Clin Pharm Ther. 2021 Dec;46(6):1757-1763. doi: 10.1111/jcpt.13522. Epub 2021 Sep 6.

DOI:10.1111/jcpt.13522

PMID:34490636

Abstract

WHAT IS KNOWN AND OBJECTIVE

Depression is most important psychological problem that is much prevalent in women than men. Obesity and depression are the leading causes of both physical and mental disability and the link between these disorders had not explored well. The present study evaluated the link between the depression, Body mass index (BMI) and the components of metabolic syndrome (MetS) in subjects with, without insulin resistance.

METHODS

A total of 150 subjects, vital and biochemical parameters were measured for eligible screened subjects in the trial of weight loss intervention at first visit. A self-reported Patient Health Questionnaire (PHQ-9) scale was used to assess the depression among the participants. The association of BMI and MetS components with risk of depression was analysed using multiple logistic regression analysis in subjects with and without insulin resistance.

RESULTS

Obesity was associated with highly significant increase in risk of depression (OR = 13.01, 95% CI 4.40-38.49) as compared to overweight subjects. Female subjects with obesity had a greater risk for depression (β: 3.725, OR: 42.62, 95% CI: 5.74-316.3 and p < 0.0001) than male subjects (β: 1.922, OR: 6.83, 95% CI: 1.8-26 and p = 0.005), and it was statistically significant. There was no association between other models (IR and MetS) and depression in both genders (p < 0.05).

WHAT IS NEW AND CONCLUSION

The odds of depression was 42.62 times more in obese women and 6.83 time more in obese men compared to overweight subjects. Subjects those who are having ≥3 metabolic syndrome (MetS) components, increased the risk of depression by 0.75 times in women and 1.50 times in men. In view of these results of our study, we conclude that the body mass index is an individual strong predictor of depression whereas metabolic syndrome and insulin resistance had no significant association with depression.

摘要

已知和目的

抑郁症是最重要的心理问题，在女性中的发病率明显高于男性。肥胖和抑郁症是身体和精神残疾的主要原因，而这两种疾病之间的联系尚未得到充分探索。本研究评估了在有或没有胰岛素抵抗的受试者中，抑郁症、体重指数（BMI）和代谢综合征（MetS）成分之间的联系。

方法

在首次就诊时，对减肥干预试验中符合条件的筛选受试者测量了总人数和生化参数。使用自我报告的患者健康问卷（PHQ-9）量表评估参与者的抑郁情况。在有或没有胰岛素抵抗的受试者中，使用多变量逻辑回归分析来分析 BMI 和 MetS 成分与抑郁风险的关系。

结果

与超重受试者相比，肥胖与抑郁风险显著增加（OR=13.01，95%CI 4.40-38.49）有关。肥胖的女性受试者患抑郁症的风险更高（β：3.725，OR：42.62，95%CI：5.74-316.3，p<0.0001），高于男性受试者（β：1.922，OR：6.83，95%CI：1.8-26，p=0.005），差异有统计学意义。在两性中，其他模型（IR 和 MetS）与抑郁之间均无关联（p<0.05）。

创新与结论

与超重受试者相比，肥胖女性患抑郁症的几率是肥胖男性的 42.62 倍，肥胖男性患抑郁症的几率是肥胖男性的 6.83 倍。在女性中，患有≥3 种代谢综合征（MetS）成分的受试者患抑郁症的风险增加了 0.75 倍，而男性的风险增加了 1.50 倍。鉴于我们研究的结果，我们得出结论，体重指数是个体患抑郁症的一个强有力的预测因素，而代谢综合征和胰岛素抵抗与抑郁症没有显著关联。