Denny W A, Atwell G J, Baguley B C
Cancer Research Laboratory, University of Auckland School of Medicine, New Zealand.
Anticancer Drug Des. 1987 Dec;2(3):263-70.
A series of analogues of amsacrine have been prepared by replacing the acridine with a variety of other chromophores, in a search for 'minimal' DNA-intercalating anti-tumour agents which might show superior distributive properties as a consequence of lower levels of binding to cellular macromolecules. 2-Styrylquinoline derivatives did show in vivo anti-leukaemic activity, but none of the compounds was superior to amsacrine itself.
通过用多种其他发色团取代吖啶，制备了一系列安吖啶类似物，以寻找 “最小化” 的DNA嵌入抗肿瘤剂，由于与细胞大分子的结合水平较低，这些药剂可能具有更好的分布特性。2-苯乙烯基喹啉衍生物确实显示出体内抗白血病活性，但没有一种化合物优于安吖啶本身。
