• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

吡嗪重氮氢氧化物钠盐（NSC-361456）的合成、化学稳定性及临床前抗肿瘤活性

Synthesis, chemical stability and pre-clinical anti-tumor activity of pyrazine diazohydroxide, sodium salt (NSC-361456).

作者信息

Baker D C, Hand E S, Plowman J, Rampal J B, Safavy A, Haugwitz R D, Narayanan V L

机构信息

Department of Chemistry, University of Alabama, Tuscaloosa 35487-9671.

出版信息

Anticancer Drug Des. 1987 Dec;2(3):297-309.

PMID:3449093
Abstract

The synthesis, chemical stability and anti-tumor activity of pyrazine diazohydroxide, sodium salt, a compound that has been selected for development to clinical trials, are described. The compound shows a half-life of about 100 minutes at pH 7.4 and is active against a number of experimental tumors.

摘要

本文描述了吡嗪重氮氢氧化物钠盐的合成、化学稳定性和抗肿瘤活性，该化合物已被选定用于开展临床试验。该化合物在pH 7.4时的半衰期约为100分钟，对多种实验性肿瘤具有活性。

相似文献

1
Synthesis, chemical stability and pre-clinical anti-tumor activity of pyrazine diazohydroxide, sodium salt (NSC-361456).吡嗪重氮氢氧化物钠盐（NSC-361456）的合成、化学稳定性及临床前抗肿瘤活性
Anticancer Drug Des. 1987 Dec;2(3):297-309.
2
Phase I evaluation and pharmacokinetic study of pyrazine-2-diazohydroxide administered as a single bolus intravenous injection in patients with advanced solid tumors.对晚期实体瘤患者单次静脉推注吡嗪 - 2 - 重氮氢氧化物的I期评估及药代动力学研究。
Cancer Res. 1993 Oct 15;53(20):4843-9.
3
Activity of a novel 4-quinolinecarboxylic acid, NSC 368390 [6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarb oxylic acid sodium salt], against experimental tumors.一种新型4-喹啉羧酸NSC 368390[6-氟-2-(2'-氟-1,1'-联苯-4-基)-3-甲基-4-喹啉羧酸钠盐]对实验性肿瘤的活性
Cancer Res. 1985 Nov;45(11 Pt 1):5563-8.
4
Schedule dependence, activity against natural metastases, and cross-resistance of pyrazine diazohydroxide (sodium salt, NSC 361456) in preclinical models in vivo.吡嗪重氮氢氧化物（钠盐，NSC 361456）在体内临床前模型中的时间依赖性、对自然转移灶的活性及交叉耐药性。
Cancer Chemother Pharmacol. 1990;25(6):425-9. doi: 10.1007/BF00686053.
5
[Compounds with presumable antitumor activity. III. 1-Substituted N,N'-di-2-pyrimidinyl (or pyrazinyl)methylenediamine].
Farmaco Sci. 1984 Sep;39(9):797-805.
6
[Synthesis and antibacterial and antitumoral activity of some methylhydrazonium salts of pyrimidine bases and their analogues (author's transl)].嘧啶碱及其类似物的一些甲基肼盐的合成、抗菌和抗肿瘤活性（作者译）
Pharmazie. 1982 May;37(5):355-6.
7
Structure-activity relationships of pyrazine-based CK2 inhibitors: synthesis and evaluation of 2,6-disubstituted pyrazines and 4,6-disubstituted pyrimidines.基于吡嗪的CK2抑制剂的构效关系：2,6-二取代吡嗪和4,6-二取代嘧啶的合成与评价
Arch Pharm (Weinheim). 2008 Sep;341(9):554-61. doi: 10.1002/ardp.200700269.
8
Activity of a novel anthracenyl bishydrazone, 9,10-anthracenedicarboxyaldehyde Bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride, against experimental tumors in mice.新型蒽基双腙9,10-蒽二甲醛双[(4,5-二氢-1H-咪唑-2-基)腙]二盐酸盐对小鼠实验性肿瘤的活性
Cancer Res. 1982 Feb;42(2):440-4.
9
2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.2,4-二氨基-5-脱氮-6-取代吡啶并[2,3-d]嘧啶抗叶酸剂作为二氢叶酸还原酶的强效和选择性非经典抑制剂。
J Med Chem. 1996 Mar 29;39(7):1438-46. doi: 10.1021/jm950786p.
10
Synthesis and SAR of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents.
Bioorg Med Chem. 2009 Jan 1;17(1):111-8. doi: 10.1016/j.bmc.2008.11.016. Epub 2008 Nov 14.

引用本文的文献

1
A phase II trial of pyrazine diazohydroxide in patients with disseminated malignant melanoma and no prior chemotherapy--Southwest Oncology Group study.吡嗪重氮氢氧化物用于播散性恶性黑色素瘤且未接受过化疗患者的II期试验——西南肿瘤协作组研究
Invest New Drugs. 2002 Feb;20(1):105-11. doi: 10.1023/a:1014484821460.
2
Pyrazine diazohydroxide (NSC-361456). Phase I clinical and pharmacokinetic studies.
Invest New Drugs. 1994;12(3):207-16. doi: 10.1007/BF00873961.
3
Schedule dependence, activity against natural metastases, and cross-resistance of pyrazine diazohydroxide (sodium salt, NSC 361456) in preclinical models in vivo.吡嗪重氮氢氧化物（钠盐，NSC 361456）在体内临床前模型中的时间依赖性、对自然转移灶的活性及交叉耐药性。
Cancer Chemother Pharmacol. 1990;25(6):425-9. doi: 10.1007/BF00686053.
4
Comparative toxicity of fostriecin, hepsulfam and pyrazine diazohydroxide to human and murine hematopoietic progenitor cells in vitro.
Invest New Drugs. 1991 May;9(2):149-57. doi: 10.1007/BF00175082.