吡嗪重氮氢氧化物钠盐（NSC-361456）的合成、化学稳定性及临床前抗肿瘤活性
Synthesis, chemical stability and pre-clinical anti-tumor activity of pyrazine diazohydroxide, sodium salt (NSC-361456).
作者信息
Baker D C, Hand E S, Plowman J, Rampal J B, Safavy A, Haugwitz R D, Narayanan V L
机构信息
Department of Chemistry, University of Alabama, Tuscaloosa 35487-9671.
出版信息
Anticancer Drug Des. 1987 Dec;2(3):297-309.
PMID:3449093
Abstract
The synthesis, chemical stability and anti-tumor activity of pyrazine diazohydroxide, sodium salt, a compound that has been selected for development to clinical trials, are described. The compound shows a half-life of about 100 minutes at pH 7.4 and is active against a number of experimental tumors.
摘要
本文描述了吡嗪重氮氢氧化物钠盐的合成、化学稳定性和抗肿瘤活性，该化合物已被选定用于开展临床试验。该化合物在pH 7.4时的半衰期约为100分钟，对多种实验性肿瘤具有活性。
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